Tsutsumi K, Saavedra J M
Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Endocrinology. 1991 Jan;128(1):630-2. doi: 10.1210/endo-128-1-630.
Angiotensin II receptors in selected brain areas were characterized into two distinct subtypes by displacement with specific antagonists. The receptor subtypes had different developmental patterns. Type-1 receptors, selectively displaced by the specific angiotensin antagonist DuP-753, were predominant in adult (8-weeks-old) rats. Type-2 receptors were selectively displaced by CGP 42112 A and were expressed remarkably in young (2-weeks-old) rats.
通过用特异性拮抗剂进行置换，对选定脑区的血管紧张素II受体进行了表征，分为两种不同的亚型。这两种受体亚型具有不同的发育模式。1型受体可被特异性血管紧张素拮抗剂DuP-753选择性置换，在成年（8周龄）大鼠中占主导地位。2型受体可被CGP 42112 A选择性置换，在幼年（2周龄）大鼠中显著表达。
