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关于各种细菌滤液引起局部皮肤反应的特异性和性质。

CONCERNING THE SPECIFICITY AND NATURE OF THE PHENOMENON OF LOCAL SKIN REACTIVITY TO VARIOUS BACTERIAL FILTRATES.

机构信息

Laboratories of the Mount Sinai Hospital, New York.

出版信息

J Exp Med. 1930 Mar 31;51(4):571-83. doi: 10.1084/jem.51.4.571.

DOI:10.1084/jem.51.4.571
PMID:19869711
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2131843/
Abstract

The specifcity and the nature of the phenomenon of local skin reactivity to various microorganisms have been studied. It has been shown that the skin preparatory and reacting factors of various biologically and serologically unrelated microorganisms are able to substitute for each other, provided they have the power of eliciting the phenomenon for themselves. Additional evidence has been brought concerning the antigenic specificity of the factors eliciting the phenomenon. A variety of nonbacterial substances which are able to increase the permeability of capillaries, elicit inflammation and "block" the reticulo-endothelial cells; failed to induce the state of local skin reactivity to B. typhosus culture filtrate. Non-bacterial protein substances (crystalline egg albumin and normal horse serum) failed to reproduce the phenomenon. It was not possible to obtain passive transfer of the local skin reactivity. Various conditions influencing the potency of the bacterial culture filtrates have been pointed out. The essential nature of the phenomenon has been discussed together with its significance in relationship to disease.

摘要

已经研究了局部皮肤对各种微生物的反应现象的特异性和性质。结果表明，具有自身引发现象能力的各种生物和血清学上无关的微生物的皮肤预备和反应因子能够相互替代。关于引发现象的因子的抗原特异性提供了更多的证据。许多能够增加毛细血管通透性、引发炎症和“阻塞”网状内皮细胞的非细菌性物质，未能诱导对 B. typhosus 培养液的局部皮肤反应状态。非细菌性蛋白质物质（结晶卵白蛋白和正常马血清）未能重现该现象。未能获得局部皮肤反应的被动转移。已经指出了影响细菌培养液效力的各种条件。讨论了现象的本质及其与疾病的关系。

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本文引用的文献

1
STUDIES ON BACILLUS TYPHOSUS TOXIC SUBSTANCES : III. THE EFFECT OF SERA UPON THE INJURY PRODUCING FACTORS OF THE PHENOMENON OF LOCAL SKIN REACTIVITY.关于伤寒杆菌毒素物质的研究：III. 血清对局部皮肤反应现象产生损伤因子的影响。
J Exp Med. 1929 Sep 30;50(4):513-20. doi: 10.1084/jem.50.4.513.
2
STUDIES ON BACILLUS TYPHOSUS TOXIC SUBSTANCES : II. THE EFFECT OF SERA UPON THE FACTORS DETERMINING LOCAL SKIN REACTIVITY TO FILTRATES OF BACILLUS TYPHOSUS CULTURES.关于伤寒杆菌毒素物质的研究：II. 血清对决定局部皮肤对伤寒杆菌培养滤液反应性的因素的影响。
J Exp Med. 1929 Mar 31;49(4):593-602. doi: 10.1084/jem.49.4.593.

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