家兔皮内注射肺炎球菌及其产物的反应：Ⅳ. 对肺炎球菌衍生物的皮肤反应性的发展。
REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : IV. THE DEVELOPMENT OF SKIN REACTIVITY TO DERIVATIVES OF PNEUMOCOCCUS.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1930 Mar 31;51(4):625-32. doi: 10.1084/jem.51.4.625.
Abstract
- A skin reaction elicited by the injection of the Pneumococcus "nucleoprotein," or of a solution of the cells from which the acid and heat-coagulable proteins have been removed is described in rabbits which have previously received repeated intracutaneous injections of heat-killed pneumococci. 2. In terms of bacterial specificity, the skin reaction is considered to be not type-specific, but species-specific. 3. A similar skin reaction to the proteins of Pneumococcus occurs in rabbits following the repeated administration by the intravenous or intracutaneous route of the heat-killed organisms or their protein derivatives. 4. The skin reaction may occur independently of resistance to infection. 5. The skin reaction appears to be related to the presence of circulating species-specific antibodies.
摘要
先前接受过多次经皮热灭活肺炎球菌注射的兔子，在注射肺炎球菌“核蛋白”或已去除酸和热凝固蛋白的细胞溶液后，会引发皮肤反应。
就细菌特异性而言，皮肤反应被认为不是型特异性的，而是种特异性的。
经静脉或皮内途径重复给予热灭活的生物体或其蛋白质衍生物后，兔子体内也会发生类似于肺炎球菌蛋白的类似皮肤反应。
皮肤反应可能独立于抗感染能力而发生。
皮肤反应似乎与循环种特异性抗体的存在有关。
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