家兔皮内注射肺炎球菌及其产物的反应：六、对肺炎球菌及其产物的过敏反应。

REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : VI. HYPERSENSITIVENESS TO PNEUMOCOCCI AND THEIR PRODUCTS.

机构信息

Hospital of The Rockefeller Institute for Medical Research.

出版信息

J Exp Med. 1930 Mar 31;51(4):643-57. doi: 10.1084/jem.51.4.643.

DOI:10.1084/jem.51.4.643

PMID:19869717

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2131836/

Abstract

Rabbits receiving either intracutaneous or intravenous injections of crystalline egg albumin acquire a "skin sensitivity" but not an "eye sensitivity" to the albumin. 2. Rabbits receiving either intracutaneous or intravenous injections of the "nucleoprotein" of Pneumococcus acquire a specific "skin sensitivity" to the "nucleoprotein" but not an "eye sensitivity." 3. Rabbits receiving intravenous injections of a suspension of heat-killed pneumococci acquire a "skin hypersensitiveness" but not an "eye hypersensitiveness" to the "nucleoprotein." 4. The skin hypersensitiveness to the respective proteins is associated with the presence of antibodies in the blood and is transferable by the injection of serum from an actively sensitized to a normal rabbit. 5. Rabbits receiving intracutaneous injections of a suspension of heat-killed pneumococci also acquire a "skin hypersensitiveness" to the "nucleoprotein" of the cell, but they may acquire an eye hypersensitiveness as well. 6. Rabbits injected intracutaneously with a suspension of heat-killed pneumococci show a primary and a secondary skin reaction following the first injection. The intensity of the reactions increases with subsequent injections up to the fourth to the sixth injection. With later injections these reactions change in character and decrease in intensity. These reactions bear no apparent relation to the presence of antibodies in the blood. 7. Rabbits injected intracutaneously with a suspension of heat-killed pneumococci develop "eye hypersensitiveness" which, under the experimental conditions, is not transferable from "eye reactive" to normal rabbits. 8. It appears, therefore, that following the injection of heat-killed pneumococci into the skin a special kind of "eye" and "skin hypersensitiveness" develops which is not related to the presence of circulating antibodies and which cannot be transferred from the sensitive to normal rabbits.

摘要

接受结晶白蛋白皮内或静脉注射的兔子获得对白蛋白的“皮肤敏感性”，但不获得对白蛋白的“眼敏感性”。
接受肺炎球菌“核蛋白”皮内或静脉注射的兔子对“核蛋白”获得特异性“皮肤敏感性”，但不获得对核蛋白的“眼敏感性”。
接受加热杀死肺炎球菌混悬液静脉注射的兔子对“核蛋白”获得“皮肤过敏”，但不获得对核蛋白的“眼过敏”。
各自蛋白质的皮肤过敏与血液中抗体的存在有关，并且可通过从主动致敏的兔子向正常兔子注射血清来传递。
接受加热杀死肺炎球菌混悬液皮内注射的兔子对细胞的“核蛋白”也获得“皮肤过敏”，但它们也可能获得眼过敏。
接受加热杀死肺炎球菌混悬液皮内注射的兔子在第一次注射后显示出原发性和继发性皮肤反应。随着随后的注射，反应的强度增加，直到第四至第六次注射。在随后的注射中，这些反应的性质发生变化，强度降低。这些反应与血液中抗体的存在没有明显关系。
接受加热杀死肺炎球菌混悬液皮内注射的兔子发展出“眼过敏”，在实验条件下，这种眼过敏不能从“眼反应性”兔子转移到正常兔子。
因此，似乎在将加热杀死的肺炎球菌注入皮肤后，会发展出一种特殊的“眼”和“皮肤过敏”，与循环抗体的存在无关，并且不能从敏感兔子转移到正常兔子。