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家兔对皮内注射肺炎球菌及其产物的反应:五、对肺炎球菌衍生物产生眼反应性的发展。

REACTIONS OF RABBITS TO INTRACUTANEOUS INJECTIONS OF PNEUMOCOCCI AND THEIR PRODUCTS : V. THE DEVELOPMENT OF EYE REACTIVITY TO DERIVATIVES OF PNEUMOCOCCI.

机构信息

Hospital of The Rockefeller Institute for Medical Research.

出版信息

J Exp Med. 1930 Mar 31;51(4):633-42. doi: 10.1084/jem.51.4.633.

Abstract
  1. About two-thirds of the rabbits injected intracutaneously with suspensions of heat-killed S or R pneumococci develop an increased eye reactivity. 2. Eye reactions in these animals may be elicited by the instillation of "nucleoprotein," or of a solution of Pneumococcus from which the acid precipitable and heat coagulable proteins have been removed. The eye reactions are not elicited, under the conditions described, by living R cells or the protein-free, type-specific, polysaccharides. 3. Rabbits do not develop an increased eye reactivity following intravenous injections of the intact cell. 4. Rabbits do not develop an increased eye reactivity following injections of soluble derivatives of Pneumococcus. 5. Experimental infection by Pneumococcus may stimulate eye reactivity in rabbits. 6. Eye reactivity occurs in animals actively resistant to infection. 7. Eye reactions are observed more frequently in rabbits which show the secondary reaction.
摘要
  1. 约三分之二的经皮内注射热灭活 S 或 R 型肺炎球菌悬液的兔子会出现眼部反应增强。

  2. 这些动物的眼部反应可以通过滴注“核蛋白”或已去除可沉淀酸和热凝固蛋白的肺炎球菌溶液来引发。在描述的条件下,活 R 细胞或无蛋白、型特异性多糖不会引起眼部反应。

  3. 兔子经静脉注射完整细胞后不会出现眼部反应增强。

  4. 兔子经肺炎球菌可溶性衍生物注射后不会出现眼部反应增强。

  5. 肺炎球菌的实验感染可能会刺激兔子的眼部反应。

  6. 具有抗感染活性的动物会发生眼部反应。

  7. 出现二次反应的兔子中更频繁地观察到眼部反应。

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