枯草芽孢杆菌的一些紫外显微照片。

SOME ULTRAVIOLET PHOTOMICROGRAPHS OF B. SUBTILIS.

Laboratories of The Rockefeller Institute for Medical Research.

J Exp Med. 1931 Jul 31;54(3):449-51. doi: 10.1084/jem.54.3.449.

Abstract

Type-specific antipneumococcus immunity has been induced in rabbits by immunization with antigen prepared by combining a specific derivative of the capsular polysaccharide of Type III Pneumococcus with globulin from horse serum. 2. Rabbits immunized with this antigen acquire active immunity against infection with virulent Type III pneumococci. 3. The sera of the immune rabbits contain type-specific antibodies which precipitate the Type III capsular polysaccharide, agglutinate Type III pneumococci, and specifically protect mice against Type III infection. 4. The experimental data are discussed with reference to: (1) the concurrence in the immune sera of type-specific antibodies for Pneumococcus and precipitins for horse globulin; (2) the determining influence of the capsular polysaccharide on the specificity of the antigen as a whole; (3) the unity of the type-specific precipitins, agglutinins, and protective antibodies induced by a single compo of the pneu mococcus in chemical union with an unrelated, animal protein.

摘要

通过用 III 型肺炎球菌荚膜多糖的特异衍生物与马血清球蛋白结合制备抗原免疫家兔，诱导了针对各种型别肺炎球菌的特异免疫性。
用这种抗原免疫的家兔获得了针对 III 型强毒肺炎球菌感染的主动免疫力。
免疫家兔的血清含有针对 III 型荚膜多糖的型特异性抗体，能沉淀 III 型荚膜多糖，凝集 III 型肺炎球菌，并能特异性地保护小鼠免受 III 型感染。
用下列各点来讨论实验资料：（1）免疫血清中存在肺炎球菌的型特异性抗体和马球蛋白沉淀素；（2）荚膜多糖对整个抗原特异性的决定作用；（3）用化学结合法把肺炎球菌的单一成分与一种无关的动物蛋白质结合后，能诱导出型特异性沉淀素、凝集素和保护性抗体的统一性。