糖基-蛋白质的化学免疫研究：十二、含有纤维二糖醛酸的人工抗原的免疫学特性。
CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : XII. THE IMMUNOLOGICAL PROPERTIES OF AN ARTIFICIAL ANTIGEN CONTAINING CELLOBIURONIC ACID.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1938 Sep 30;68(4):469-84. doi: 10.1084/jem.68.4.469.
Abstract
- Artificial antigens containing the azobenzyl glycosides of the disaccharide cellobiose and the aldobionic acid, cellobiuronic acid, give rise in rabbits to antibodies which are specific and characteristic of the saccharide constituent. The antiserum to cellobiuronic acid shows broader serological cross reactions than does that to cellobiose. 2. An antiserum to the cellobiuronic acid antigen precipitates the capsular polysaccharide of Type III Pneumococcus when the latter is combined with a heterologous protein. 3. The cellobiuronic acid test antigen precipitates vigorously in antipneumococcus sera Types II, III, and VIII. The mechanism of these reactions is discussed.
摘要
含有二糖纤维二糖和 aldobionic 酸、纤维二糖醛酸的人工抗原，在兔子中产生的抗体是针对糖成分的特异性和特征性的。抗纤维二糖醛酸的血清比抗纤维二糖的血清具有更广泛的血清学交叉反应。
抗纤维二糖醛酸抗原的抗血清在将 III 型肺炎球菌荚膜多糖与异源蛋白结合时会沉淀。
纤维二糖醛酸测试抗原在 II、III 和 VIII 型抗肺炎球菌血清中强烈沉淀。讨论了这些反应的机制。
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