亚甲蓝对体温和代谢的影响。
ACTION OF METHYLENE BLUE ON BODY TEMPERATURE AND METABOLISM.
机构信息
Department of Biological Chemistry, Washington University School of Medicine, St. Louis.
出版信息
J Exp Med. 1931 Nov 30;54(6):827-45. doi: 10.1084/jem.54.6.827.
Abstract
- Methylene blue injected intravenously in white rats is hyperthermizing or hypothermizing according to the environmental temperature. 2. It causes an increase in metabolism at 28 degrees C. or above. At lower temperature it does not affect, or rather depresses, metabolism. 3. It does not seem likely that its hypermetabolic action is due to catalysis of cell oxidations. 4. In animals exposed to an atmosphere with a high partial pressure of oxygen, methylene blue causes pulmonary edema, much more rapidly than does oxygen alone.
摘要
静脉注射亚甲蓝的大白鼠，其体温可因环境温度而升高或降低。
在 28°C 或高于 28°C 时，它会引起代谢率增加。在较低温度时，它不影响，或更确切地说，会抑制代谢率。
它的引起代谢亢进的作用似乎不是由于细胞氧化的催化作用。
暴露在高氧分压空气中的动物，亚甲蓝引起肺水肿，比单纯用氧要快得多。
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本文引用的文献
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THE CATALYTIC EFFECT OF METHYLENE BLUE ON THE OXYGEN CONSUMPTION OF TUMORS AND NORMAL TISSUES.亚甲蓝对肿瘤和正常组织耗氧量的影响。
J Exp Med. 1930 Aug 31;52(3):447-56. doi: 10.1084/jem.52.3.447.
2
STUDIES ON BLOOD CELL METABOLISM : I. THE EFFECT OF METHYLENE BLUE AND OTHER DYES UPON THE OXYGEN CONSUMPTION OF MAMMALIAN AND AVIAN ERYTHROCYTES.血液细胞代谢研究：I. 亚甲蓝和其他染料对哺乳动物和禽类红细胞耗氧量的影响。
J Exp Med. 1928 Jul 31;48(2):207-23. doi: 10.1084/jem.48.2.207.
3
OXYGEN POISONING IN MAMMALS.哺乳动物的氧中毒。
J Exp Med. 1927 Apr 30;45(5):849-64. doi: 10.1084/jem.45.5.849.
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A new form of Apparatus for measuring the Respiratory Exchange of Animals.一种用于测量动物呼吸交换的新型仪器。
J Physiol. 1892 Jul;13(5):419-30. doi: 10.1113/jphysiol.1892.sp000417.
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