作为抗原的胶体吸附碳水化合物。

CARBOHYDRATES ADSORBED ON COLLOIDS AS ANTIGENS.

机构信息

Mulford Biological Laboratories, Sharp and Dohme, Glenolden, Pennsylvania.

出版信息

J Exp Med. 1932 Feb 29;55(3):325-51. doi: 10.1084/jem.55.3.325.

DOI:10.1084/jem.55.3.325

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2132113/

Abstract

Evidence is here given that polysaccharides can be rendered antigenic by haptogenic adsorption upon a colloid carrier. The polysaccharides studied were those of B. anthracis, the meningococcus, Streptococcus viridans (Bargen), B. proteus, S. morgani, B. dysenteriae, both the Shiga and Hiss types, and the pneumococci. With the polysaccharide of Type III pneumococci, we have been unable in 6 weeks to produce any detectable protective antibodies, but we were able to produce anticarbohydrate antibodies. All the bacterial carbohydrates were non-antigenic alone when used in the doses indicated, though containing some nitrogen. Dextran, which was free from nitrogen was also rendered antigenic by the adsorption method.

摘要

现已有证据表明，通过半抗原吸附到胶体载体上，多糖可以具有抗原性。所研究的多糖有炭疽杆菌、脑膜炎球菌、草绿色链球菌（Bargen）、变形杆菌、摩根菌、痢疾杆菌（志贺氏和希氏菌型）和肺炎球菌。对于 III 型肺炎球菌多糖，我们在 6 周内未能产生任何可检测到的保护性抗体，但我们能够产生抗碳水化合物抗体。当使用所指示的剂量时，所有细菌的碳水化合物单独使用时都没有抗原性，尽管它们含有一些氮。葡聚糖不含氮，通过吸附法也具有抗原性。

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