用肺炎球菌多糖型 I、II 和 III 对小鼠进行主动免疫。
ACTIVE IMMUNIZATION OF MICE WITH THE POLYSACCHARIDES OF PNEUMOCOCCI TYPES I, II AND III.
机构信息
Mulford Biological Laboratories, Sharp and Dohme, Glenolden, Pennsylvania.
出版信息
J Exp Med. 1933 Jan 1;57(1):21-40. doi: 10.1084/jem.57.1.21.
Abstract
- Pneumococcus polysaccharides Types I, II and III adsorbed on collodion particles, and Types I and III adsorbed on carbon (norit) are antigenic in mice. 2. Unadsorbed pneumococcus polysaccharide of Type I is antigenic in mice in proper dilution. One preparation of Type II polysaccharide was not antigenic, while another one immunized against Types I and II. Type III polysaccharide was only slightly antigenic against Type III but immunized against Type I. 3. The antigenicity of pneumococcus polysaccharide in optimal dosage is tentatively explained by an adsorption phenomenon taking place in the body in instances in which the polysaccharides had not been adsorbed before injection. 4. The aggressin-like action of large doses of pneumococcus polysaccharides Types I, II and III is further established.
摘要
用胶体粒子吸附的肺炎球菌多糖 I、II 和 III 型，以及用炭（诺里特）吸附的 I 和 III 型，在小鼠体内具有抗原性。
适当稀释的 I 型未吸附肺炎球菌多糖在小鼠体内具有抗原性。II 型多糖的一种制剂无抗原性，而另一种则对 I 型和 II 型具有免疫原性。III 型多糖对 III 型仅有微弱的抗原性，但对 I 型具有免疫原性。
在最佳剂量下，肺炎球菌多糖的抗原性可以通过在体内发生的吸附现象来解释，这种吸附现象发生在多糖在注射前没有被吸附的情况下。
进一步证实了大剂量 I、II 和 III 型肺炎球菌多糖的类侵袭素样作用。
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