Laboratory Division of Montefiore Hospital, New York.
J Exp Med. 1932 Nov 30;56(6):783-92. doi: 10.1084/jem.56.6.783.
The effect on Bartonella muris anemia of adding copper or iron or both to an adequate diet was studied. The addition to the diet of copper (0.1 mg. per rat per day), or iron (1 mg. per day), or both during a period of 2 days prior to splenectomy and 1 month subsequent thereto failed to protect adult albino rats against Bartonella muris anemia. The addition of copper to an adequate diet for a period of 10 days prior to splenectomy and 1 month subsequent thereto protected 75 per cent of the rats against the anemia. The addition of iron (1 mg. per rat per day) for a period of 10 days prior to and 1 month subsequent to splenectomy protected 50 per cent of the rats against this anemia. The addition of both copper and iron for a period of 10 days prior to and 1 month subsequent to splenectomy protected 75 per cent of these rats against Bartonella muris anemia. The addition of copper alone for a period of 2 months prior to and 1 month subsequent to splenectomy protected 63 per cent of the rats against Bartonella muris anemia. The addition of iron, or of both copper and iron during a period of 2 months prior to splenectomy and 1 month subsequent thereto protected about one-third of the rats against Bartonella murisanemia.
研究了在充足饮食中添加铜或铁或两者对鼠巴尔通体贫血的影响。在脾切除术之前的 2 天和之后的 1 个月期间，饮食中添加铜（每天每只大鼠 0.1 毫克）或铁（每天 1 毫克）或两者均不能保护成年白化大鼠免受鼠巴尔通体贫血的影响。在脾切除术之前的 10 天和之后的 1 个月期间，将铜添加到充足的饮食中，可使 75％的大鼠免受贫血的影响。在脾切除术之前和之后的 10 天期间，每天每只大鼠添加 1 毫克铁可使 50％的大鼠免受这种贫血的影响。在脾切除术之前和之后的 10 天期间，同时添加铜和铁可使 75％的这些大鼠免受鼠巴尔通体贫血的影响。在脾切除术之前和之后的 2 个月期间单独添加铜可使 63％的大鼠免受鼠巴尔通体贫血的影响。在脾切除术之前和之后的 2 个月期间添加铁或铜和铁均可使约三分之一的大鼠免受鼠巴尔通体贫血的影响。
