关于白化大鼠巴尔通体贫血的研究：III. 自体脾移植对脾切除大鼠巴尔通体贫血的保护作用。
STUDIES ON BARTONELLA MURIS ANEMIA OF ALBINO RATS : III. THE PROTECTIVE EFFECT OF AUTOPLASTIC SPLENIC TRANSPLANTS ON THE BARTONELLA MURIS ANEMIA OF SPLENECTOMIZED RATS.
机构信息
Laboratory Division, Montefiore Hospital, New York.
出版信息
J Exp Med. 1930 Jun 30;52(1):131-43. doi: 10.1084/jem.52.1.131.
Autoplastic splenic transplants were made in adult albino rats 4 weeks and 7 weeks prior to splenectomy and the protective effects against infection with the Bartonella muris anemia observed. 1. One-fourth of the spleen left in situ will protect adult albino rats against the Bartonella muris anemia. 2. Autotransplantation of splenic tissue in adult rats is successful in over 90 per cent of instances. 3. Autoplastic splenic transplants performed 7 weeks prior to splenectomy afford protection against Bartonella muris anemia in more than 50 per cent of instances, whereas 4 week old transplants do not protect. 4. A comparative histological study of the transplants of protected and unprotected rats reveals a regeneration of the pulp cells in the protected rats and an exhaustion destruction of the pulp in the unprotected rats. 5. The reticular cells play a specific rôle in protecting the adult albino rat against Bartonella muris anemia.
自体脾移植在脾切除前 4 周和 7 周的成年白化大鼠中进行，并观察到对感染伯氏考克斯氏体贫血的保护作用。1. 保留在原位的四分之一脾脏可保护成年白化大鼠免受伯氏考克斯氏体贫血的影响。2. 成年大鼠的脾组织自体移植成功率超过 90%。3. 脾切除前 7 周进行的自体脾移植可使超过 50%的大鼠免受伯氏考克斯氏体贫血的影响，而 4 周龄的移植则不能保护。4. 对受保护和未受保护大鼠的移植进行比较组织学研究表明，受保护大鼠的髓细胞再生，而未受保护大鼠的髓细胞耗尽破坏。5. 网状细胞在保护成年白化大鼠免受伯氏考克斯氏体贫血方面起着特定的作用。
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