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关于白化大鼠巴尔通体贫血的研究：I. 与巴尔通体贫血相关的正常白化大鼠感染锥虫利什曼原虫 II. 成年正常大鼠的潜伏感染。

STUDIES ON BARTONELLA MURIS ANEMIA OF ALBINO RATS : I. TRYPANOSOMA LEWISI INFECTION IN NORMAL ALBINO RATS ASSOCIATED WITH BARTONELLA MURIS ANEMIA II. LATENT INFECTION IN ADULT NORMAL RATS.

机构信息

Laboratory Division, Montefiore Hospital, New York.

出版信息

J Exp Med. 1930 Jun 30;52(1):121-9. doi: 10.1084/jem.52.1.121.

DOI:10.1084/jem.52.1.121
PMID:19869745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2131866/
Abstract
  1. The virus of Bartonella muris anemia of splenectomized rats may be transmitted to normal young unoperated rats and rabbits. This confirms the observations of Ford and Eliot. 2. Trypanosoma lewisi infections in normal adult rats are accompanied by an anemia most marked at the height of the infection and the appearance of Bartonella muris bodies in the red blood cells. 3. In young rats Trypanosoma lewisi may produce death from the severity of the anemia, complicating the disease. The anemic virus may be separated from the Trypanosoma lewisi infected blood by passage through young rabbits with subsequent maintenance of the strain in immature rats. 4. A strain of the virus of Bartonella muris anemia capable of producing an anemia in young rabbits and young rats for successive transfers has been isolated from the blood of normal adult unoperated rats by passage through young rabbits. 5. The adult normal rat is a carrier of the Bartonella muris virus. 6. Splenectomy in young suckling rats separated from the mother is not followed by a Bartonella muris anemia. The young suckling rat is not a carrier of the infection.
摘要

  1. 已切除脾脏的老鼠贫血症巴尔通体病毒可能会传播给正常的未手术幼鼠和兔子。这证实了 Ford 和 Eliot 的观察结果。

  2. 正常成年大鼠感染锥虫利什曼原虫会伴有贫血，在感染高峰期最为明显，并且红细胞中出现巴尔通体菌。

  3. 在幼鼠中，锥虫利什曼原虫可能因贫血严重而导致死亡，使疾病复杂化。贫血病毒可通过幼兔传递，从感染锥虫利什曼原虫的血液中分离出来，随后在未成熟的大鼠中维持该病毒株。

  4. 已从正常成年未手术大鼠的血液中通过幼兔传递，分离出一种能够在幼兔和幼鼠中连续传代引起贫血的巴尔通体贫血症病毒株。

  5. 成年正常大鼠是巴尔通体病毒的携带者。

  6. 从母亲那里分离出来的幼龄哺乳期大鼠的脾切除术不会导致巴尔通体贫血症。幼龄哺乳期大鼠不是感染的携带者。

相似文献

1
STUDIES ON BARTONELLA MURIS ANEMIA OF ALBINO RATS : I. TRYPANOSOMA LEWISI INFECTION IN NORMAL ALBINO RATS ASSOCIATED WITH BARTONELLA MURIS ANEMIA II. LATENT INFECTION IN ADULT NORMAL RATS.关于白化大鼠巴尔通体贫血的研究：I. 与巴尔通体贫血相关的正常白化大鼠感染锥虫利什曼原虫 II. 成年正常大鼠的潜伏感染。
J Exp Med. 1930 Jun 30;52(1):121-9. doi: 10.1084/jem.52.1.121.
2
THE TRANSFER OF RAT ANEMIA TO NORMAL ANIMALS.将大鼠贫血转移至正常动物。
J Exp Med. 1928 Sep 30;48(4):475-92. doi: 10.1084/jem.48.4.475.
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THE ETIOLOGY OF BARTONELLA MURIS ANEMIA OF THE ALBINO RAT : THE ISOLATION OF BARTONELLA MURIS.贝氏疏螺旋体鼠贫血症的病因：贝氏疏螺旋体的分离。
J Exp Med. 1932 Oct 31;56(5):763-75. doi: 10.1084/jem.56.5.763.
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FURTHER STUDIES ON T. LEWISI INFECTION IN ALBINO RATS : I. THE EFFECT OF SPLENECTOMY ON T. LEWISI INFECTION IN ALBINO RATS AND THE PROTECTIVE ACTION OF SPLENIC AUTOTRANSPLANTS II. THE EFFECT OF THYMECTOMY AND BILATERAL GONADECTOMY ON T. LEWISI INFECTION IN ALBINO RATS.进一步研究李氏锥虫感染白化大鼠：I. 脾切除术对白化大鼠李氏锥虫感染的影响及脾自体移植的保护作用 II. 甲状腺切除术和双侧性腺切除术对白化大鼠李氏锥虫感染的影响。
J Exp Med. 1930 Sep 30;52(4):601-16. doi: 10.1084/jem.52.4.601.
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J Exp Med. 1930 Jun 30;52(1):131-43. doi: 10.1084/jem.52.1.131.
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STUDIES ON BARTONELLA MURIS ANEMIA : VII. THE PROTECTIVE ACTION OF COPPER AND IRON AGAINST BARTONELLA MURIS ANEMIA.关于贝氏疏螺旋体贫血病的研究：VII. 铜和铁对贝氏疏螺旋体贫血病的保护作用。
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STUDIES ON BARTONELLA MURIS ANEMIA : VI. A LIPOID EXTRACT OF THE SPLEEN THAT PREVENTS BARTONELLA MURIS ANEMIA IN SPLENECTOMIZED ALBINO RATS.关于巴尔通体鼠贫血的研究：六、一种脾脏脂类提取物，可预防脾切除白化病大鼠的巴尔通体鼠贫血。
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J Exp Med. 1928 Jan 31;47(2):235-43. doi: 10.1084/jem.47.2.235.

引用本文的文献

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STUDIES ON BARTONELLA MURIS ANEMIA : VIII. CHANGES IN THE CHEMICAL CONSTITUENTS OF THE BLOOD DURING THE ANEMIA.关于贝纳柯克斯体贫血的研究：VIII. 贫血期间血液化学成分的变化。
J Exp Med. 1933 Jan 1;57(1):81-93. doi: 10.1084/jem.57.1.81.
2
STUDIES ON BARTONELLA MURIS ANEMIA : VI. A LIPOID EXTRACT OF THE SPLEEN THAT PREVENTS BARTONELLA MURIS ANEMIA IN SPLENECTOMIZED ALBINO RATS.关于巴尔通体鼠贫血的研究：六、一种脾脏脂类提取物，可预防脾切除白化病大鼠的巴尔通体鼠贫血。
J Exp Med. 1932 Nov 30;56(6):777-82. doi: 10.1084/jem.56.6.777.
3
THE ETIOLOGY OF BARTONELLA MURIS ANEMIA OF THE ALBINO RAT : THE ISOLATION OF BARTONELLA MURIS.贝氏疏螺旋体鼠贫血症的病因：贝氏疏螺旋体的分离。
J Exp Med. 1932 Oct 31;56(5):763-75. doi: 10.1084/jem.56.5.763.
4
THE EFFECT OF BILATERAL SUPRARENALECTOMY IN ADULT ALBINO RATS ON THE NATURAL AND ACQUIRED RESISTANCE TO BARTONELLA MURIS ANEMIA.双侧肾上腺切除术对成年白化大鼠天然和获得性抵抗巴氏杆菌贫血的影响。
J Exp Med. 1932 Jan 1;55(1):109-19. doi: 10.1084/jem.55.1.109.
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J Exp Med. 1931 May 31;53(6):877-83. doi: 10.1084/jem.53.6.877.
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[The influence of the spleen on the white blood picture].[脾脏对白细胞图像的影响]
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本文引用的文献

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ETIOLOGY OF OROYA FEVER : XII. INFLUENCE OF MALARIAL INFECTION (PLASMODIUM INUI?), SPLENECTOMY, OR BOTH, UPON EXPERIMENTAL CARRION'S DISEASE IN MONKEYS.奥罗亚热的病因：十二. 疟原虫（恶性疟原虫？）感染、脾切除术及二者对猴尸体腐败病的影响。
J Exp Med. 1928 Apr 30;47(5):821-7. doi: 10.1084/jem.47.5.821.
2
ETIOLOGY OF OROYA FEVER : XI. COMPARISON OF BARTONELLA BACILLIFORMIS AND BARTONELLA MURIS. CULTIVATION OF BACTERIUM MURIUM, N. SP.奥罗亚热病因学：十一。杆菌状巴尔通体与鼠巴尔通体的比较。新种鼠巴尔通体的培养。
J Exp Med. 1928 Jan 31;47(2):235-43. doi: 10.1084/jem.47.2.235.
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THE ETIOLOGY OF VERRUGA PERUANA.秘鲁疣的病因。
J Exp Med. 1927 Jan 1;45(1):175-89. doi: 10.1084/jem.45.1.175.