• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
THE COMPLEMENT FIXATION REACTION WITH PNEUMOCOCCUS CAPSULAR POLYSACCHARIDE.肺炎球菌荚膜多糖的补体固定反应。
J Exp Med. 1936 Jul 31;64(2):201-16. doi: 10.1084/jem.64.2.201.
2
The role of the capsular polysaccharide in the activation of the alternative pathway by the pneumococcus.荚膜多糖在肺炎球菌激活替代途径中的作用。
J Immunol. 1976 Feb;116(2):367-70.
3
THE ROLE OF THE COMPONENTS OF COMPLEMENT IN SPECIFIC IMMUNE FIXATION.补体成分在特异性免疫固定中的作用。
J Exp Med. 1942 Apr 1;75(4):421-35. doi: 10.1084/jem.75.4.421.
4
CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : V. THE IMMUNOLOGICAL SPECIFITY OF AN ANTIGEN PREPARED BY COMBINING THE CAPSULAR POLYSACCHARIDE OF TYPE III PNEUMOCOCCUS WITH FOREIGN PROTEIN.糖蛋白的化学免疫研究：V. 用 III 型肺炎球菌荚膜多糖与异源蛋白结合制备的抗原的免疫学特异性。
J Exp Med. 1931 Jul 31;54(3):437-47. doi: 10.1084/jem.54.3.437.
5
CUTANEOUS REACTIONS IN RABBITS TO THE TYPE-SPECIFIC CAPSULAR POLYSACCHARIDES OF PNEUMOCOCCUS.兔对肺炎球菌特异性荚膜多糖的皮肤反应。
J Exp Med. 1931 Sep 30;54(4):587-96. doi: 10.1084/jem.54.4.587.
6
IMMUNOLOGICAL STUDIES ON PURE CULTURES OF VARIOUS SPIROCHETES.各种螺旋体纯培养的免疫学研究。
J Exp Med. 1917 Jun 1;25(6):765-88. doi: 10.1084/jem.25.6.765.
7
Quantitative studies of complement fixation; fixation of complement in the reaction between type III pneumococcus specific polysaccharide and homologous antibody.补体结合定量研究；III型肺炎球菌特异性多糖与同源抗体反应中的补体结合
J Immunol. 1948 Oct;60(2):205-12.
8
DECOMPOSITION OF THE CAPSULAR POLYSACCHARIDE OF PNEUMOCOCCUS TYPE III BY A BACTERIAL ENZYME.III 型肺炎球菌荚膜多糖的细菌酶降解。
J Exp Med. 1931 Jun 30;54(1):51-71. doi: 10.1084/jem.54.1.51.
9
Surface-bound capsular polysaccharide of type Ia group B Streptococcus mediates C1 binding and activation of the classic complement pathway.Ia型B族链球菌的表面结合荚膜多糖介导C1结合和经典补体途径的激活。
J Immunol. 1986 Jun 1;136(11):4157-62.
10
PROPERTIES OF THE TYPE SPECIFIC PROTEINS OF ANTIPNEUMOCOCCUS SERA : II. IMMUNOLOGICAL FRACTIONATION OF TYPE I ANTIPNEUMOCOCCUS HORSE AND RABBIT SERA.抗肺炎球菌血清的特异性蛋白质特性：II. Ⅰ型抗肺炎球菌马和兔血清的免疫学分离。
J Exp Med. 1937 Sep 30;66(4):425-35. doi: 10.1084/jem.66.4.425.

引用本文的文献

1
THE PNEUMOCOCCAL CAPSULAR SWELLING REACTION, STUDIED WITH THE AID OF THE ELECTRON MICROSCOPE.肺炎球菌荚膜肿胀反应的电子显微镜研究。
J Exp Med. 1943 Nov 1;78(5):327-32. doi: 10.1084/jem.78.5.327.
2
QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : III. UPTAKE OF COMPLEMENT NITROGEN UNDER VARYING EXPERIMENTAL CONDITIONS.补体或激肽化学的定量研究：三、在不同实验条件下补体氮的摄取。
J Exp Med. 1941 Sep 30;74(4):359-67. doi: 10.1084/jem.74.4.359.
3
QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : II. THE INTERRELATION OF COMPLEMENT WITH ANTIGEN-ANTIBODY COMPOUNDS AND WITH SENSITIZED RED CELLS.补体或备解素的定量化学研究：Ⅱ.补体与抗原-抗体复合物及致敏红细胞的关系。
J Exp Med. 1941 May 31;73(6):695-709. doi: 10.1084/jem.73.6.695.
4
QUANTITATIVE CHEMICAL STUDIES ON COMPLEMENT OR ALEXIN : I. A METHOD.补体或激肽定量化学研究：一、方法。
J Exp Med. 1941 May 31;73(6):681-94. doi: 10.1084/jem.73.6.681.
5
Studies on the mechanism of hypersensitivity phenomena. II. The participation of complement in passive cutaneous anaphylaxis of the albino rat.过敏反应现象机制的研究。II. 补体在白化大鼠被动皮肤过敏反应中的作用。
J Exp Med. 1957 Dec 1;106(6):811-34. doi: 10.1084/jem.106.6.811.

本文引用的文献

1
CHEMOIMMUNOLOGICAL STUDIES ON THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS : I. THE ISOLATION AND PROPERTIES OF THE ACETYL POLYSACCHARIDE OF PNEUMOCOCCUS TYPE I.肺炎球菌可溶性特异物质的化学免疫学研究：I. 肺炎球菌 I 型乙酰多糖的分离与特性。
J Exp Med. 1933 Nov 30;58(6):731-55. doi: 10.1084/jem.58.6.731.
2
SPECIFIC PRECIPITATION AND MOUSE PROTECTION IN TYPE I ANTIPNEUMOCOCCUS SERA.Ⅰ型抗肺炎球菌血清中的特异性沉淀及小鼠保护作用。
J Exp Med. 1930 Sep 30;52(4):477-83. doi: 10.1084/jem.52.4.477.
3
A QUANTITATIVE STUDY OF THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND PURIFIED HOMOLOGOUS ANTIBODY.Ⅲ型肺炎球菌多糖与纯化同源抗体沉淀反应的定量研究。
J Exp Med. 1929 Nov 30;50(6):809-23. doi: 10.1084/jem.50.6.809.
4
CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS : II. IMMUNOLOGICAL SPECIFICITY OF SYNTHETIC SUGAR-PROTEIN ANTIGENS.糖蛋白-结合物的化学免疫研究：II. 合成糖蛋白抗原的免疫学特异性。
J Exp Med. 1929 Sep 30;50(4):533-50. doi: 10.1084/jem.50.4.533.

肺炎球菌荚膜多糖的补体固定反应。

THE COMPLEMENT FIXATION REACTION WITH PNEUMOCOCCUS CAPSULAR POLYSACCHARIDE.

机构信息

Hospital of The Rockefeller Institute for Medical Research.

出版信息

J Exp Med. 1936 Jul 31;64(2):201-16. doi: 10.1084/jem.64.2.201.

DOI:10.1084/jem.64.2.201
PMID:19870530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180314/
Abstract
  1. Complement is not fixed by immune aggregates resulting from the interaction of pneumococcus capsular polysaccharide and type-specific immune horse serum, although under proper conditions the substitution of immune rabbit serum gives positive results. 2. The negative results with immune horse serum are due to some poorly understood property of the specific antibodies rather than to some heterologous inhibitor present in the serum. 3. It has been shown that with immune rabbit serum-polysaccharide combinations, complement fixation is an adsorptive phenomenon conditioned upon the surface exposure of the immune aggregates. 4. A close parallelism to the selective adsorption of phosphatides by these immune aggregates has been pointed out. 5. In those instances in which complement is fixed this phenomenon must be regarded as tertiary and conditioned by (a) union of antigen and antibody, and (b) particulation. 6. The general significance of complement fixation as applied to bacterial polysaccharides has been discussed.
摘要

  1. 虽然在适当条件下，免疫兔血清的替代会产生阳性结果，但补体不是由肺炎球菌荚膜多糖与特异性免疫马血清相互作用产生的免疫复合物所固定。

  2. 免疫马血清的阴性结果是由于特异性抗体的一些尚未完全了解的特性所致，而不是由于血清中存在某些异源抑制剂。

  3. 已经证明，对于免疫兔血清-多糖复合物，补体固定是一种吸附现象，取决于免疫复合物表面的暴露。

  4. 已经指出，这与这些免疫复合物对磷脂的选择性吸附密切平行。

  5. 在补体固定的情况下，这种现象必须被视为三级现象，并取决于(a)抗原和抗体的结合，以及(b)颗粒化。

  6. 已经讨论了补体固定在细菌多糖中的一般意义。