Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1936 Aug 31;64(3):385-400. doi: 10.1084/jem.64.3.385.
All the strains of the Shope virus thus far tested which give rise to vigorous, progressively enlarging papillomas in domestic rabbits, function as carcinogenic agents by way of these growths. The more pathogenic the virus as evidenced by the brevity of its incubation period and the vigor of the papillomas produced, the sooner and oftener does cancer occur. The number of virus entities contained in the inoculum notably influences the outcome, cancer appearing most frequently in those confluent, papillomatous masses which have resulted from the greatest concentration of the virus material under test. The papillomas experimentally induced by the ordinary inoculation methods are essentially aggregates of proliferating cell families, each the outcome of some primary cell-virus association. Some of these associations are followed more frequently by cancer than others are in the same animal. Cottontail rabbits, the natural hosts of the virus, are notably resistant to its sustained activity, as compared with domestic rabbits. Though often growing rapidly at first, the papillomas of cottontails soon become relatively inert in most cases, and they usually retrogress, and rarely undergo malignant change. In an instance here reported both a squamous cell carcinoma and a metastasizing sarcoma appeared at the base of some papillomas due to experimental inoculation, which had existed on the ears of a cottontail for nearly 2 years. The meaning of the phenomena is discussed.
迄今所测试的所有肖普氏病毒株，在兔体上引起剧烈、进行性增大的乳头瘤，皆通过这些生长物而起致癌作用。病毒的致病力越强，即潜伏期越短，产生的乳头瘤越剧烈，则癌症发生得越早、越频繁。接种物中包含的病毒数量明显影响结果，在因试验材料浓度最高而形成的融合性乳头瘤块中，癌症最常出现。用通常的接种方法诱发的乳头瘤实质上是增生细胞家族的聚集，每个都是某种原始细胞-病毒联合体的结果。在同一动物中，有些联合体比其他联合体更频繁地导致癌症。与家兔相比，病毒的天然宿主棉尾兔对其持续活动有明显的抵抗力。虽然最初通常生长迅速，但在大多数情况下，棉尾兔的乳头瘤很快变得相对惰性，它们通常退化，很少发生恶性变化。在本报告的一个实例中，由于实验接种，在棉尾兔耳朵上存在近 2 年的一些乳头瘤的基部，出现了一个鳞状细胞癌和一个转移肉瘤。讨论了这些现象的意义。
