Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1936 Oct 31;64(5):771-90. doi: 10.1084/jem.64.5.771.
Intracerebral inoculation of tuberde bacilli into normal guinea pigs induces acute meningoencephalitis with minor metastatic lesions. The disease is fatal in a relatively short time and is characterized by a rather typical succession of symptoms and a fairly characteristic temperature curve. The disease is produced by very small numbers of bacilli; and under standard conditions, survival time is so uniform as to make possible quantitative or titration experiments. Certain possible applications of the method are discussed.
将结核杆菌脑内接种于正常豚鼠，可引起急性脑膜脑炎，并伴有轻微的转移性损害。这种疾病在相对较短的时间内是致命的，其特征是症状有相当典型的先后顺序，以及相当特征性的温度曲线。这种疾病是由非常少量的细菌引起的；在标准条件下，存活时间非常一致，因此可以进行定量或滴定实验。本文讨论了该方法的某些可能的应用。
