Biological Division, Department of Medicine, Johns Hopkins Medical School and Hospital, Baltimore.
J Exp Med. 1937 Jan 1;65(1):147-61. doi: 10.1084/jem.65.1.147.
Sera obtained from patients at the time of acute active infections were found, in every instance, to be bactericidal for hemolytic streptococci. The observations were made with sera from twenty-five patients. The group consisted of cases of pneumococcus, hemolytic streptococcus, staphylococcus, meningococcus, tubercle bacillus, and malarial infections; the etiology of the diseases in other patients was either uncertain or may have been a mixed infection. In sera taken from the same group of patients, soon after recovery or marked improvement had taken place, the streptococcidal property was absent or greatly diminished in potency. By comparative tests made with sera from twenty healthy adults, the streptococcidal action was not demonstrable. Three different strains of Streptococcus hemolyticus of the beta type were employed in the experiments. Differences in susceptibility of the strains to the killing power of the serum were noted.
从急性活动感染患者获得的血清，在每种情况下都被发现对溶血性链球菌具有杀菌作用。这些观察是用 25 名患者的血清进行的。该组包括肺炎球菌、溶血性链球菌、葡萄球菌、脑膜炎球菌、结核杆菌和疟疾感染的病例；其他患者的病因不确定，或者可能是混合感染。在同一组患者康复或明显改善后不久采集的血清中，链球菌杀菌特性缺失或效力大大降低。通过与 20 名健康成年人的血清进行比较试验，未发现链球菌杀菌作用。实验中使用了三种不同的β型溶血性链球菌菌株。注意到菌株对血清杀菌能力的敏感性存在差异。
