Department of Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, N. Y.
J Exp Med. 1937 Oct 31;66(5):565-78. doi: 10.1084/jem.66.5.565.
It has been shown that the standard anemic dog can use sheep, goose or dog hemoglobin when given by vein and return quantitatively its equivalent as new dog hemoglobin within the red cells. Globin at times can be used when given by vein with a quantitative return of new hemoglobin in red cells in these same anemic dogs. Again the administration of globin by vein will inhibit the expected hemoglobin formation; and we believe the toxic effect of the globin is responsible. A digest of globin may be used by the anemic dog to form new hemoglobin. Globin from both horse and dog have been tested and seem to react in identical fashion. The globin radicle of hemoglobin appears to be an important limiting factor in abundant hemoglobin building in this type of anemia due to blood loss. Globin fed by mouth is well utilized to form new hemoglobin and we may record a 30 to 40 per cent utilization or a return of 30 to 40 gm. new hemoglobin from the feeding of 100 gm. globin. This is to be compared with the utilization of liver protein-an average return of 13 gm. new hemoglobin for the feeding of 100 gm. liver protein.
已经证明，标准贫血犬在静脉内给予绵羊、鹅或狗血红蛋白时可以使用，并在红细胞内定量返回其相当于新的狗血红蛋白。球蛋白有时可以静脉内给予，在这些相同的贫血犬中，红细胞内定量返回新的血红蛋白。再次，静脉内给予球蛋白会抑制预期的血红蛋白形成；我们认为球蛋白的毒性作用是负责的。贫血犬可能会利用球蛋白的消化产物来形成新的血红蛋白。已经测试了来自马和狗的球蛋白，它们似乎以相同的方式反应。由于失血导致的这种贫血症中，血红蛋白的球蛋白根源似乎是大量血红蛋白生成的重要限制因素。口服给予的球蛋白可很好地用于形成新的血红蛋白，我们可以记录从 100 克球蛋白喂养中获得 30%至 40%的利用率或 30 至 40 克新血红蛋白的返回。这与肝蛋白的利用率进行比较，喂养 100 克肝蛋白可平均返回 13 克新血红蛋白。
