经肠外给予的酪蛋白消化物可用于形成血浆蛋白质。
CASEIN DIGESTS PARENTERALLY UTILIZED TO FORM BLOOD PLASMA PROTEIN.
机构信息
Department of Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, New York.
出版信息
J Exp Med. 1941 May 31;73(6):727-43. doi: 10.1084/jem.73.6.727.
When blood plasma proteins are depleted by bleeding with return of the washed red cells (plasmapheresis) it is possible to bring dogs to a steady state of hypoproteinemia and a uniform plasma protein production on a basal diet limited in protein. Such dogs are clinically normal but have a lowered resistance to infection and certain intoxications. Casein digests given by vein or subcutaneously to such plasma depleted dogs are effective in promoting abundant new plasma protein production. Casein digest L by vein is equivalent to whole liver of like protein equivalence by mouth. The ratio of new plasma protein production to protein intake is 20 to 25 per cent in both instances. Casein digest L by vein gives the same response in plasma protein output as the same digest by mouth. Protein digest X by vein requires addition of tryptophane and cysteine to be effective in plasma protein production. The added cysteine sulfur is more than 95 per cent retained by the dog. The speed of digest injection has no effect on its utilization, within the range tested. Casein digest L given by vein to non-depleted dogs is less well utilized than in dogs depleted of plasma protein.
当通过出血并用洗涤后的红细胞（血浆分离术）回输来耗尽血浆蛋白时，有可能使狗处于低蛋白血症的稳定状态，并在限制蛋白质的基础饮食上产生均匀的血浆蛋白生成。这样的狗在临床上是正常的，但对感染和某些中毒的抵抗力降低。静脉内或皮下给予这种血浆耗竭的狗酪蛋白消化物可有效地促进大量新的血浆蛋白生成。静脉内的酪蛋白消化物 L 相当于口服相同蛋白质等价物的整个肝脏。在这两种情况下，新的血浆蛋白生成与蛋白质摄入的比例均为 20%至 25%。静脉内的酪蛋白消化物 L 在血浆蛋白输出方面与口服相同的消化物产生相同的反应。静脉内的蛋白消化物 X 要有效地产生血浆蛋白生成，需要添加色氨酸和半胱氨酸。由狗保留的添加的半胱氨酸硫超过 95%。在测试范围内，消化物注射的速度对其利用没有影响。静脉内给予非耗竭狗的酪蛋白消化物不如在血浆蛋白耗竭的狗中利用得好。
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