Department of Pathology, Cornell University Medical College, and New York Hospital, New York.
J Exp Med. 1937 Nov 30;66(6):761-88. doi: 10.1084/jem.66.6.761.
Heat killed tubercle bacilli repeatedly injected into or below the skin of rabbits increase conspicuously their resistance against infection with virulent tubercle bacilli. Protection against tuberculous infection following the administration of heat killed tubercle bacilli to rabbits is only slightly less than that given by BCG. Addition of certain antigens, notably heated horse serum, increases the protection given by heat killed tubercle bacilli so that it is approximately the same as that afforded by BCG. These experiments and tentative observations of persons exposed to tuberculous infection indicate that heat killed tubercle bacilli may be substituted for the living attenuated microorganism in the attempt to increase resistance against tuberculous infection and to influence favorably the delicate balance between asymptomatic or latent infection and progressive manifest disease that is characteristic of human tuberculosis.
反复将加热杀死的结核杆菌注入或注射到兔子的皮肤下，会显著提高其对有毒结核杆菌感染的抵抗力。给兔子注射加热杀死的结核杆菌可提供的结核感染防护作用，略低于卡介苗。添加某些抗原，特别是加热的马血清，可增加加热杀死的结核杆菌的保护作用，使其与卡介苗的保护作用大致相同。这些实验和对接触结核感染人群的初步观察表明，加热杀死的结核杆菌可替代活的减毒微生物，以试图提高对结核感染的抵抗力，并有利于影响无症状或潜伏感染与人类结核病的典型进行性显性疾病之间的微妙平衡。
