甲状腺在调节兔血液胆固醇中的作用。

THE ROLE OF THE THYROID IN THE REGULATION OF THE BLOOD CHOLESTEROL OF RABBITS.

Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York.

J Exp Med. 1938 Jan 1;67(1):111-27. doi: 10.1084/jem.67.1.111.

Abstract

The blood cholesterol of rabbits on a normal diet without added cholesterol is increased only slightly (19 per cent) by thyroidectomy. 2. In rabbits with a hypercholesterolemia due to long continued cholesterol feeding, thyroidectomy causes a marked rise (137 per cent) in the blood cholesterol. This rise is usually maintained. 3. When long continued cholesterol feeding has failed to cause a rise in the blood cholesterol of rabbits, thyroidectomy abolishes this resistance and a hypercholesterolemia is promptly produced. 4. A single injection of thyroxin causes a significant drop in the blood cholesterol of rabbits with hypercholesterolemia. This reaction is not influenced by thyroidectomy. 5. Potassium iodide causes an increase in the blood cholesterol of rabbits with hypercholesterolemia. This reaction is not influenced by thyroidectomy in contrast to the effect of KI in preventing a rise in blood cholesterol when given concurrently from the beginning of cholesterol feeding, an effect which is abolished by thyroidectomy. It is suggested that two different mechanisms are involved. 6. A single injection of insulin produces a fall in the blood cholesterol of rabbits with hypercholesterolemia. If anything, thyroidectomy increases the magnitude of this effect.

摘要

正常饮食、未额外添加胆固醇的兔子的血胆固醇水平经甲状腺切除术处理后仅轻度升高（19%）。
在因长期持续给予胆固醇而出现高胆固醇血症的兔子中，甲状腺切除术会导致血胆固醇显著升高（137%）。这种升高通常会维持。
当长期持续给予胆固醇未能导致兔子的血胆固醇升高时，甲状腺切除术消除了这种抵抗，迅速产生高胆固醇血症。
甲状腺素单次注射会导致高胆固醇血症兔子的血胆固醇显著下降。这种反应不受甲状腺切除术的影响。
碘化钾会增加高胆固醇血症兔子的血胆固醇水平。与 KI 从开始给予胆固醇喂养时即可防止血胆固醇升高的作用相反，甲状腺切除术不影响这种反应，而这种作用被甲状腺切除术所消除。这表明涉及两种不同的机制。
胰岛素单次注射会导致高胆固醇血症兔子的血胆固醇下降。甲状腺切除术甚至可能增加这种效果的幅度。