Rodgers J B, Tang G, Bochenek W J
Department of Medicine, Albany Medical College, NY 12208.
Am J Med Sci. 1989 Sep;298(3):177-81. doi: 10.1097/00000441-198909000-00006.
Poloxalene, a hydrophobic surfactant, is known to prevent hypercholesterolemia in animals fed a high-fat, high-cholesterol diet. It has not been demonstrated, however, whether this agent is of benefit when hypercholesterolemia is induced in animals by means other than the feeding of a high-fat diet. In this study, hypercholesterolemia was produced in rabbits by feeding a low-fat, cholesterol-free diet with dietary protein supplied by casein for a period of 8 weeks. Controls were given this diet without poloxalene and experimentals were given the diet with poloxalene. Total serum cholesterol levels increased in both groups, but the rise was greater for the control group. Lipoprotein analysis performed at the conclusion of the study showed significantly greater low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol levels in the control group as compared to the experimental group. Total protein and apolipoprotein B (apo B) were also greater in control LDL. It was concluded that poloxalene favorably affects this model of hypercholesterolemia as total serum cholesterol, LDL cholesterol, and LDL apo B were all less and the HDL cholesterol to LDL cholesterol ratio was higher in surfactant-treated rabbits.
泊洛沙林是一种疏水表面活性剂，已知它能预防喂食高脂、高胆固醇饮食的动物出现高胆固醇血症。然而，尚未证实当通过高脂饮食以外的方式诱导动物出现高胆固醇血症时，这种药物是否有益。在本研究中，通过给兔子喂食低脂、无胆固醇饮食（饮食中的蛋白质由酪蛋白提供）持续8周来诱导其出现高胆固醇血症。对照组给予不含泊洛沙林的这种饮食，实验组给予含泊洛沙林的饮食。两组的血清总胆固醇水平均升高，但对照组的升高幅度更大。研究结束时进行的脂蛋白分析显示，与实验组相比，对照组的低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇水平显著更高。对照LDL中的总蛋白和载脂蛋白B（apo B）也更高。得出的结论是，泊洛沙林对这种高胆固醇血症模型有有利影响，因为在经表面活性剂处理的兔子中，血清总胆固醇、LDL胆固醇和LDL apo B均较低，且HDL胆固醇与LDL胆固醇的比值更高。
