Departments of Pathology and Bacteriology, Duke University School of Medicine, Durham, North Carolina.
J Exp Med. 1938 Jan 31;67(2):309-22. doi: 10.1084/jem.67.2.309.
Experiments are reported which show that the virulent Bordet-Gengou bacillus can produce a significant lymphocytosis and an interstitial mononuclear pneumonia in both the monkey and the rabbit. Both of these reactions occur apparently as the result of a toxic material formed in vivo from the Bordet-Gengou bacillus and are not dependent on the multiplication of the organism itself. It was also shown that the strictly avirulent form could also cause an interstitial mononuclear pneumonia but no lymphocytosis. This interstitial mononuclear pneumonia was thought to be the result of the foreign substance produced by the organism when it was in this stage. This was substantiated by the fact that this lesion could be produced both by living and dead organisms.
现报道实验结果表明，强毒博德特-戈登氏杆菌可在猴和兔体内引起显著的淋巴细胞增多和间质性单核细胞性肺炎。这两种反应显然都是由博德特-戈登氏杆菌在体内形成的毒性物质引起的，而不依赖于该生物体自身的繁殖。还表明，严格的无毒形式也可引起间质性单核细胞性肺炎，但不会引起淋巴细胞增多。这种间质性单核细胞性肺炎被认为是该生物体处于这一阶段时产生的异物的结果。这一事实证实了无论是活的还是死的生物体都可以产生这种病变。
