Rockefeller Institute for Medical Research, New York.
J Exp Med. 1909 Jan 9;11(1):41-54. doi: 10.1084/jem.11.1.41.
The bacillus of Bordet and Gengou is present in the sputum in early cases of pertussis, and in the lungs at autopsy in fatal cases of the disease. After the second week it is not present in the sputum in sufficiently large numbers to be readily isolated. The influenza bacillus is found at as early a stage of pertussis as is the Bordet-Gengou bacillus, and it persists in the sputum for a longer time. The agglutinins in the blood of pertussis patients are not more regular and not always higher for the Bordet-Gengou bacillus than for B. influenzae. The two organisms are culturally distinct and their action on laboratory animals different. Complement deviation tests with the serum of immunized rabbits show a further difference in the immune bodies produced by the two varieties of bacilli. The negative results of the complement deviation tests with the patients' serum in this study, compared with the positive results of similar tests made by Bordet and Gengou, I am not able to account for. This study has contributed support to the view that the Bordet-Gengou bacillus is the possible cause of pertussis, but it has not produced any distinctively new evidence of this relationship beyond the proof of the wide dissemination of the peculiar bacillus in nature and its occurrence in pertussis. A study of bronchial secretions in other acute diseases of the respiratory tract for the bacillus has not yet been extensively made and is called for. I shall hope to report on this phase of the subject at another time.
白喉和戈登杆菌存在于百日咳早期患者的痰液中，在疾病的致命病例的尸检中存在于肺部。第二周后，它在痰液中的数量不足以轻易分离。流感杆菌在百日咳的早期阶段就像白喉和戈登杆菌一样被发现，并且在痰液中持续存在的时间更长。百日咳患者血液中的凝集素对于白喉和戈登杆菌来说并不比流感嗜血杆菌更规律，也不一定更高。这两种生物体在文化上是不同的，它们对实验室动物的作用也不同。用免疫兔血清进行补体偏离试验显示，两种杆菌产生的免疫体进一步不同。与博德特和戈登的类似试验相比，本研究中患者血清的补体偏离试验的阴性结果，我无法解释。这项研究支持了白喉和戈登杆菌可能是百日咳的病因的观点，但除了证明这种特殊杆菌在自然界中的广泛传播及其在百日咳中的发生之外，并没有提供任何明显的新证据证明这种关系。尚未广泛研究其他呼吸道急性疾病的支气管分泌物中是否存在这种杆菌，这是值得研究的。我将希望在另一个时间报告这个课题的这一方面。
