各种动物血液中的流感病毒生长抑制物质：利用各种动物血液作为选择性培养基检测咽培养物中的溶血性链球菌。

A GROWTH INHIBITORY SUBSTANCE FOR THE INFLUENZA GROUP OF ORGANISMS IN THE BLOOD OF VARIOUS ANIMAL SPECIES : THE USE OF THE BLOOD OF VARIOUS ANIMALS AS A SELECTIVE MEDIUM FOR THE DETECTION OF HEMOLYTIC STREPTOCOCCI IN THROAT CULTURES.

Irvington House, Irvington-on-Hudson, New York.

J Exp Med. 1938 Feb 28;67(3):429-41. doi: 10.1084/jem.67.3.429.

Abstract

5 per cent sheep blood agar is a selective medium for beta hemolytic streptococci in throat cultures since sheep blood inhibits the growth of bacillus X (H. hemolyticus) and B. parainfluenzae hemolyticus. The growth of H. influenzae is also inhibited by sheep blood. 2. The inhibitory action of sheep blood resides in the erythrocytes and is thermolabile. Disruption of the cell by laking has no effect upon the inhibitor. 3. The bloods of animals closely related to the sheep, such as the goat and the cow, have a similar inhibitory action on the growth of hemolytic and non-hemolytic members of the influenza group, while human blood contains a similar but less powerful inhibitor for these organisms. 4. Members of the influenza group grow well on unheated rodent blood: rabbit, guinea pig, and rat. 5. These organisms also grow fairly well on unheated horse blood.

摘要

5%绵羊血琼脂是一种用于咽培养物中β溶血性链球菌的选择性培养基，因为绵羊血抑制了巴斯德菌 X（H. 溶血）和副流感嗜血杆菌溶血的生长。流感嗜血杆菌的生长也被绵羊血抑制。
绵羊血的抑制作用存在于红细胞中，并且是热不稳定的。细胞溶解对抑制剂没有影响。
与绵羊关系密切的动物的血液，如山羊和牛，对流感组的溶血性和非溶血性成员的生长具有类似的抑制作用，而人类血液中含有对这些生物体具有类似但较弱抑制作用的物质。
流感组的成员在未加热的啮齿动物血液中生长良好：兔子、豚鼠和老鼠。
这些生物体在未加热的马血中也能相当良好地生长。