Laboratories of The Rockefeller Institute for Medical Research, New York, and the Department of Medicine, Peiping Union Medical College, Peiping, China.
J Exp Med. 1938 Feb 28;67(3):443-61. doi: 10.1084/jem.67.3.443.
Two oriental strains of T. pallidum of Chinese origin were compared with two well known occidental strains, the Nichols and the Zinsser-Hopkins, on the basis of the clinical reaction to infection in the rabbit. Four experiments were carried out, two each in Peiping and New York. Animals from American and Chinese sources were represented in each experiment. The results obtained showed that the reaction to both Chinese strains was generally comparable to that of the American strains. But with both Chinese strains, lesions of the eyes were more frequent, the time relations of certain phases of the reaction were shortened, and there was a higher incidence of complete recovery (latency) within the observation period. In view of the well known variability of the syphilitic reaction, however, it was not felt that these qualitative differences in clinical response could be ascribed to inherent or biologically fixed properties of the strains.
两种源于中国的东方梅毒螺旋体菌株与两种著名的西方菌株——尼科尔斯株和津瑟-霍普金斯株，基于在兔子身上感染的临床反应进行了比较。在中国北京和美国纽约分别进行了四项实验，每个实验都有来自美国和中国的动物。结果表明，两种中国菌株的反应通常与美国菌株相当。但对于两种中国菌株，眼部病变更为常见，反应的某些阶段的时间关系缩短，并且在观察期内完全恢复（潜伏期）的发生率更高。然而，鉴于众所周知的梅毒反应的可变性，人们认为这些临床反应的定性差异不能归因于菌株的固有或生物学固定特性。
