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A STABLE HEMOLYSIN-LEUCOCIDIN AND ITS CRYSTAL-LINE DERIVATIVE ISOLATED FROM BETA HEMOLYTIC STREPTOCOCCI.从β 溶血性链球菌中分离得到一种稳定的溶血素-白细胞毒素及其结晶衍生物。
J Exp Med. 1938 Mar 31;67(4):643-57. doi: 10.1084/jem.67.4.643.
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OXYGEN-STABLE HEMOLYSINS OF GROUP A STREPTOCOCCI. 3. THE RELATIONSHIP OF THE CELL-BOUND HOMOLYSIN TO STREPTOLYSIN S.A组链球菌的氧稳定溶血素。3. 细胞结合型溶血素与链球菌溶血素S的关系。
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SENSITIVITY TO METHYLENE BLUE AND FINAL ACIDITY OF NON-HEMOLYTIC STREPTOCOCCI.对非溶血性链球菌的亚甲蓝敏感性和最终酸度。
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本文引用的文献

1
THE TOXIC PROPERTIES OF SERUM EXTRACTS OF HEMOLYTIC STREPTOCOCCI.溶血性链球菌血清提取物的毒性。
J Exp Med. 1934 Jan 1;59(1):83-95. doi: 10.1084/jem.59.1.83.
2
ON THE MECHANISM OF OPSONIN AND BACTERIOTROPIN ACTION : I. CORRELATION BETWEEN CHANGES IN BACTERIAL SURFACE PROPERTIES AND IN PHAGOCYTOSIS CAUSED BY SERA OF ANIMALS UNDER IMMUNIZATION.关于调理素和促菌生作用的机制：I. 免疫动物血清引起的细菌表面性质变化与吞噬作用的关系。
J Exp Med. 1929 Apr 30;49(5):779-95. doi: 10.1084/jem.49.5.779.
3
STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : IV. STREPTOLYSIN.免疫物质的氧化还原研究：IV. 链道酶。
J Exp Med. 1926 Jul 31;44(2):241-60. doi: 10.1084/jem.44.2.241.

从β 溶血性链球菌中分离得到一种稳定的溶血素-白细胞毒素及其结晶衍生物。

A STABLE HEMOLYSIN-LEUCOCIDIN AND ITS CRYSTAL-LINE DERIVATIVE ISOLATED FROM BETA HEMOLYTIC STREPTOCOCCI.

机构信息

Department of Bacteriology, School of Medicine, University of Pennsylvania, Philadelphia.

出版信息

J Exp Med. 1938 Mar 31;67(4):643-57. doi: 10.1084/jem.67.4.643.

DOI:10.1084/jem.67.4.643
PMID:19870745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2133603/
Abstract
  1. A chemically pure hemolysin-leucocidin has been isolated from beta hemolytic streptococci, but not from other species of bacteria studied. 2. It does not give rise to antibodies, but precipitates immune sera against hemolytic streptococci, and is therefore a hapten. 3. A highly purified sample of S. H. up to a dilution of 1:128,000 hemolyzes red blood cells. Its hemolytic activity is not specifically neutralized by antiserum versus beta hemolytic streptococci. It is leucocidic in that it inhibits the reduction of methylene blue by leucocytes. 4. The hemolysin-leucocidin is stable to oxygen, to heat and to moderate changes in hydrogen ion concentration. Its chemical structure has been determined in part. Its molecular weight is 2260. 5. A crystalline derivative has been isolated as the sodium salt from the hemolysin-leucocidin. As the free acid it has a molecular weight of 720. Its hemolytic and leucocidic activity parallels that of S. H., although it is not serologically active. It possesses a high degree of toxicity for mice and rabbits.
摘要

  1. 一种化学纯的溶菌素-白细胞毒素已从β溶血性链球菌中分离出来，但从研究的其他细菌种中未分离出来。

  2. 它不会引起抗体，但可沉淀针对溶血性链球菌的免疫血清，因此是半抗原。

  3. 高度纯化的 S.H.样品可稀释至 1:128000 使红细胞溶血。其溶血活性不能被针对β溶血性链球菌的抗血清特异性中和。它具有白细胞毒素活性，可抑制白细胞对亚甲蓝的还原。

  4. 溶菌素-白细胞毒素对氧、热和氢离子浓度的适度变化稳定。其化学结构已部分确定。分子量为 2260。

  5. 已从溶菌素-白细胞毒素中分离出一种作为钠盐的结晶衍生物。作为游离酸，其分子量为 720。其溶血和白细胞毒素活性与 S.H.平行，尽管它在血清学上没有活性。它对小鼠和兔子具有高度毒性。