疟原虫 knowlesi 的免疫血清凝集作用。
THE AGGLUTINATION OF PLASMODIUM KNOWLESI BY IMMUNE SERUM.
机构信息
Laboratories of the International Health Division, The Rockefeller Foundation, New York.
出版信息
J Exp Med. 1938 May 31;67(6):857-70. doi: 10.1084/jem.67.6.857.
A specific agglutination of Plasmodium knowlesi detectable both by macroscopic and by microscopic methods is described. Agglutinins for Plasmodium knowlesi appear in the sera of monkeys between 15 and 45 days after the onset of the infection and become progressively stronger as the malarial infection gradually subsides. Agglutinins persist in the sera of chronically infected animals for a year or longer. The sera of animals which have been repeatedly superinfected agglutinate parasites at dilutions as high as 1:1,000. Sera from normal monkeys, from monkeys acutely ill with malaria, and from monkeys chronically infected with a different species of malarial parasite (Plasmodium inui) do not agglutinate Plasmodium knowlesi. Immune serum agglutinates mature intracellular or extracellular parasites but does not agglutinate unparasitized cells or cells containing immature parasites. The relation of these observations to the mechanism of active and passive immunity in monkey malaria is discussed.
描述了一种可通过宏观和微观方法检测到的特定疟原虫 knowlesi 凝集现象。疟原虫 knowlesi 的凝集素出现在感染开始后 15 至 45 天的猴子血清中，并随着疟原虫感染逐渐消退而逐渐增强。凝集素在慢性感染动物的血清中持续存在一年或更长时间。反复感染的动物的血清在高达 1:1000 的稀释度下仍能凝集寄生虫。来自正常猴子、疟疾急性发作的猴子和慢性感染不同疟原虫（疟原虫 inui）的猴子的血清不会凝集疟原虫 knowlesi。免疫血清凝集成熟的细胞内或细胞外寄生虫，但不凝集未寄生的细胞或含有未成熟寄生虫的细胞。这些观察结果与猴疟的主动和被动免疫机制的关系进行了讨论。
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