Laboratories of the International Health Division of The Rockefeller Foundation, New York.
J Exp Med. 1940 Jan 1;71(1):13-20. doi: 10.1084/jem.71.1.13.
It was found that with mixed malaria infections in the same experimental animal sulfanilamide eradicates a virulent P. knowlesi infection, leaving the animal with a milder chronic P. inui infection. Determinations of the metabolic activity of the two parasites in vitro showed that P. knowlesi consumed approximately six times more oxygen than P. inui. The addition of sulfanilamide in concentrations less than that necessary to effect a cure almost completely inhibited the respiration of P. knowlesi parasites in vitro, while the same concentrations of the drug against the same number of P. inui parasites had no apparent effect.
研究发现，在同一实验动物中存在混合疟原虫感染时，磺胺类药物可以根除强毒的 P. knowlesi 感染，使动物留下较轻的慢性 P. inui 感染。体外检测两种寄生虫的代谢活性表明，P. knowlesi 消耗的氧气约比 P. inui 多 6 倍。磺胺类药物的浓度低于治愈所需的浓度，几乎可以完全抑制体外 P. knowlesi 寄生虫的呼吸，但相同浓度的药物对相同数量的 P. inui 寄生虫则没有明显影响。
