肾脉冲压力降低后肾脏灌注释放肾素。

THE LIBERATION OF RENIN BY PERFUSION OF KIDNEYS FOLLOWING REDUCTION OF PULSE PRESSURE.

Lilly Laboratory for Clinical Research, Indianapolis City Hospital, Indianapolis.

J Exp Med. 1940 Jul 31;72(2):201-16. doi: 10.1084/jem.72.2.201.

Abstract

Isolated dogs' kidneys have been perfused with defibrinated blood under hemodynamic conditions similar to those in the body. Under these circumstances blood flow, urine secretion, and oxygen consumption are well maintained, but urea clearance is low. Renal venous blood collected initially and at the end of 3 or more hours of perfusion exhibited no difference in vasoconstriction properties when perfused along with renin or renin-activator through an isolated rabbit's ear. 2. Reduction of pulse pressure by constricting the renal artery may be performed without reducing mean pressure significantly. Impairment of urea clearance and rate of urine secretion follow, and oxygen consumption is slightly reduced. 3. After an hour or more of perfusion with reduced pulse pressure, gradual rise in mean renal arterial pressure distal to the clamp and reduction of blood flow occur. 4. Renal venous blood collected after about one hour of perfusion with reduced pulse pressure differs from that collected before reduction of pulse pressure in that it causes intense vasoconstriction when perfused with renin-activator through an isolated rabbit's ear. 5. Perfusion of a dog's hind leg under similar circumstances does not cause this change in the venous blood to occur.

摘要

在类似于体内的血液动力学条件下，已用纤维蛋白溶解血液对孤立的狗肾进行了灌注。在这些情况下，血流、尿液分泌和耗氧量都得到了很好的维持，但尿素清除率较低。最初收集的和在灌注 3 小时以上的肾静脉血在与肾素或肾素激活剂一起通过兔耳进行灌注时，其血管收缩特性没有差异。
通过收缩肾动脉来降低脉搏压可能不会显著降低平均压力。随后出现尿素清除率和尿液分泌率下降，耗氧量略有减少。
在进行降低脉搏压灌注 1 小时或更长时间后，夹闭处远端的平均肾动脉压逐渐升高，血流量减少。
在进行降低脉搏压灌注约 1 小时后收集的肾静脉血与降低脉搏压前收集的血液不同，因为当它与肾素激活剂一起通过兔耳进行灌注时，它会引起强烈的血管收缩。
在类似的情况下对狗后腿进行灌注不会导致静脉血液发生这种变化。