Department of Physiology, College of Physicians and Surgeons, Columbia University, New York.
J Exp Med. 1941 Aug 31;74(3):235-46. doi: 10.1084/jem.74.3.235.
Acute renal hypertension is produced by the injection of the amino acid dopa (l-dihydroxyphenylalanine) into the partially or completely ischemic kidney of the cat. Evidence is presented suggesting that the rise in blood pressure following the injection of dopa is caused by its conversion into hydroxytyramine, a pressor amine. Kidneys with normal blood flow fail to transform dopa into a pressor substance.
急性肾性高血压是由将氨基酸多巴(l-二羟苯丙氨酸)注入猫的部分或完全缺血肾脏而产生的。有证据表明,注射多巴后血压升高是由于其转化为羟酪胺,一种加压胺。血流正常的肾脏不能将多巴转化为加压物质。