巴尔通体杆菌凝集素的演示。

DEMONSTRATION OF AGGLUTININS FOR BARTONELLA BACILLIFORMIS.

Department of Comparative Pathology and Tropical Medicine, The Harvard Medical School, Boston.

J Exp Med. 1942 Jan 1;75(1):65-75. doi: 10.1084/jem.75.1.65.

Abstract

Methods of preparing a satisfactory antigen having been developed, a technique for performing an agglutination test with B. bacilliformis is made available. 2. As a result of repeated intravenous injection of living cultures of B. bacilliformis at short intervals, rabbits have been found to produce a high titre of specific agglutinins which, under the conditions obtaining in the present series of experiments, begins to decline after about one month following the last inoculation. 3. Sera from six cases of bartonellosis in different stages of its several manifestations have been shown by the agglutination test to contain a low but definite titre of circulating antibody. 4. Several of these same sera have been shown to contain as well a significantly high titre of agglutinins for three strains of Proteus. No definite conclusions can be drawn from this phenomenon since the case histories had not been probed for the possibility of typhus fever; and since the relatively high titres obtained with a few of the present sera may very well fall within the extremes of normal serum titres.

摘要

制备满意抗原的方法已经开发出来，现在可以使用一种方法用布氏杆菌进行凝集试验。
通过在短时间内反复静脉内注射活的布氏杆菌培养物，发现兔子产生了高滴度的特异性凝集素，在本系列实验中获得的条件下，自最后一次接种后约一个月开始下降。
通过凝集试验，从不同表现阶段的巴通体病的 6 例血清中显示出低但明确的循环抗体滴度。
这些相同的血清中的几种还含有针对三种变形杆菌菌株的明显高滴度的凝集素。由于病史没有被探究是否可能感染斑疹伤寒，并且由于目前一些血清中获得的相对高滴度可能很好地落在正常血清滴度的极端范围内，因此不能从这种现象得出明确的结论。