Department of Pathology, College of Physicians and Surgeons, Columbia University, New York.
J Exp Med. 1947 Mar 31;85(4):365-71. doi: 10.1084/jem.85.4.365.
Striking impairment of the antibody response to sheep erythrocytes was found in pyridoxine-deficient rats. Deficiencies in the three other B factors required by the rat, and low protein feeding, having effects on body weight comparable to pyridoxine deficiency, failed to influence the antibody response studied. Confirming previous observations, a striking loss of thymic and lymphoid tissue occurred in the pyridoxine-deficient animals. A marked deficit in thymus weight also resulted from the feeding of a diet low in thiamin. Histologically, however, lymphoid atrophy was less pronounced in thiamin-deficient rats than in those deprived of pyridoxine.
在吡哆醇缺乏的大鼠中发现对绵羊红细胞的抗体反应受到严重损害。大鼠所需的其他三种 B 因子的缺乏以及低蛋白喂养对体重的影响与吡哆醇缺乏相当,但对所研究的抗体反应没有影响。与先前的观察结果一致,在吡哆醇缺乏的动物中胸腺和淋巴组织明显丢失。由低核黄素饮食引起的胸腺重量明显不足也是如此。然而,组织学上,在缺乏核黄素的大鼠中,淋巴组织萎缩不如缺乏吡哆醇的大鼠明显。