肾上腺素能系统对心肌和骨骼肌中糖原合成酶活性的影响。
The effect of adrenergic system on glycogen synthetase activity in myocardium and skeletal muscle.
作者信息
Dynarowicz I
出版信息
Arch Immunol Ther Exp (Warsz). 1976;24(6):845-50.
The activity of glycogen synthetase after in vivo stimulation and blockade of adrenergic receptors was determined in myocardium and skeletal muscle. Stimulation of alpha-adrenergic receptor by means of phenylephrine was found to increase the activity of synthetase form I both in the heart and skeletal muscle. Isoprenaline decreases the synthetase form I activity in both muscles under study by stimulation of beta-adrenergic receptor. Adrenaline alone or administered after alpha-adrenergic receptor blockade by phenoxybenzamine acts similarly as isoprenaline. These are data at disposal that stimulation of alpha-adrenergic receptor produces in myocardium and skeletal muscle cells the changes responsible for the increase of anabolic processes in glycogen metabolism.
在体内刺激和阻断肾上腺素能受体后，测定了心肌和骨骼肌中糖原合成酶的活性。发现通过去氧肾上腺素刺激α-肾上腺素能受体可增加心脏和骨骼肌中I型合成酶的活性。异丙肾上腺素通过刺激β-肾上腺素能受体降低了所研究的两种肌肉中I型合成酶的活性。单独使用肾上腺素或在经酚苄明阻断α-肾上腺素能受体后给药，其作用与异丙肾上腺素相似。现有数据表明，刺激α-肾上腺素能受体可在心肌和骨骼肌细胞中引起糖原代谢合成过程增加的变化。
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