固体颗粒的吞噬作用：II. 碳。

THE PHAGOCYTOSIS OF SOLID PARTICLES : II. CARBON.

Laboratory of Applied Physiology, Harvard Medical School, Boston.

J Gen Physiol. 1921 Mar 20;3(4):465-82. doi: 10.1085/jgp.3.4.465.

Abstract

By measurements of the diameter and velocity of leucocytes and of the particles in two carbon suspensions, the relative rates of ingestion of the two suspensions by the leucocytes are predicted and the predictions verified experimentally. 2. The results indicate that 4.7micro particles of carbon are ingested as readily as 3.2micro particles. The more rapid apparent rate of ingestion of the 4.7micro particles is due to their greater availability rather than the greater capability of the leucocytes. 3. There is almost no phagocytosis of carbon in absence of serum or in heated serum. 4. The clumping of unwashed leucocytes is accllerated by serum and by the ingestion of carbon. 5. The available evidence indicates that the phagocytosis of bacteria does not follow the law for a monomolecular reaction, possibly because of the toxic effect upon the leucocytes of bacterial extracts.

摘要

通过对白细胞直径和速度的测量，以及对两种碳悬浮液中颗粒的测量，预测了白细胞对两种悬浮液的相对摄取率，并通过实验验证了预测。
结果表明，4.7 微米的碳颗粒与 3.2 微米的碳颗粒一样容易被摄取。4.7 微米颗粒的摄取速度明显加快，是因为它们更容易获得，而不是因为白细胞的摄取能力更强。
在没有血清或加热的血清的情况下，几乎没有碳的吞噬作用。
未清洗的白细胞的聚集被血清和碳的摄取加速。
现有证据表明，细菌的吞噬作用不符合单分子反应定律，可能是因为细菌提取物对白细胞有毒性作用。