泛酸对呼吸活动的影响。
THE EFFECTS OF PANTOTHENIC ACID ON RESPIRATORY ACTIVITY.
机构信息
Department of Chemistry, School of Science, Oregon State College, Corvallis.
出版信息
J Gen Physiol. 1939 May 20;22(5):637-47. doi: 10.1085/jgp.22.5.637.
Experiments using the Warburg-Barcroft apparatus led to the following results and conclusions: (1) Two yeasts in three different media were strikingly stimulated in their respiration by minute amounts of pantothenic acid. (2) Nine other compounds (vitamins and other biologically important substances) were tested and found in all cases to have on the deficient G.M. yeast, lesser and in some cases no appreciable stimulative effect. Thiamin was the most effective of these compounds. Its action was shown to be different and in some ways antagonistic to that of pantothenic acid. (3) Liver extract (Lilly's Number 343) contains substances capable of speeding up respiration (and growth) to a much higher level than seems possible with known compounds. (4) Pantothenic acid was found to have a definite stimulative effect on fermentation by dialyzed maceration juice from yeast. (5) It likewise stimulated respiration of apple and potato tissue and indications of a similar effect on certain animal tissues were obtained.
利用 Warburg-Barcroft 仪器进行的实验得出了以下结果和结论：
(1) 在三种不同的培养基中，两种酵母的呼吸作用受到极少量泛酸的强烈刺激。
(2) 其他九种化合物（维生素和其他具有重要生物学意义的物质）也进行了测试，在所有情况下，它们对缺乏 G.M.酵母的影响较小，在某些情况下甚至没有明显的刺激作用。硫胺素是这些化合物中最有效的一种。它的作用与泛酸不同，在某些方面是拮抗的。
(3) 肝提取物（礼来公司 343 号）含有能够加速呼吸（和生长）的物质，其水平远远超过已知化合物所能达到的水平。
(4) 发现泛酸对酵母透析浸液的发酵有明显的刺激作用。
(5) 它同样刺激了苹果和土豆组织的呼吸作用，并在某些动物组织中获得了类似的效果。
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