Division of Biological Sciences, Warwick University, Coventry, England.
J Gen Physiol. 1970 Jul 1;56(1):13-24. doi: 10.1085/jgp.56.1.13.
Virus-induced interferon formation depends on the presence within the cell of a viral ribonucleic acid. This RNA may either be double stranded or, in certain cases, single stranded. The double-stranded RNA can be derived from a virus, such as reovirus, which contains this type of RNA, or it may be synthesized within the cell using viral single-stranded RNA as a template. Single-stranded RNA must possess a stable configuration in solution to be active, and certain viral RNA molecules appear to be active for this reason. The presence of this RNA triggers a derepression event, which is probably nuclear, by an unknown mechanism, and this is followed by the production of an interferon messenger RNA and its translation. Little is known of the derepression event or the events that follow it.
病毒诱导干扰素的形成取决于细胞内是否存在病毒的核糖核酸。这种 RNA 可能是双链的，也可能在某些情况下是单链的。双链 RNA 可以来自含有这种类型 RNA 的病毒，例如呼肠孤病毒，也可以在细胞内使用病毒的单链 RNA 作为模板合成。单链 RNA 在溶液中必须具有稳定的构象才能发挥作用，某些病毒 RNA 分子似乎就是因为这个原因而具有活性。这种 RNA 的存在通过一种未知的机制触发了一个去阻遏事件，这个事件可能发生在核内，随后产生干扰素信使 RNA 并进行翻译。对于去阻遏事件或其后的事件，我们知之甚少。
