Department of Microbiology, Mount Sinai School of Medicine, New York 10029, and the National Institute for Medical Research, Mill Hill, London, England.
J Gen Physiol. 1970 Jul 1;56(1):172-83. doi: 10.1085/jgp.56.1.172.
The development of resistance in response to interferon depends on cellular RNA synthesis and probably also on cellular protein synthesis. The evidence for these requirements is reviewed, as well as the proposal that this evidence indicates the existence of a specific response of the cell to interferon, involving the induced synthesis of an antiviral protein. Direct evidence for such an interpretation has not been obtained, and alternative explanations are discussed which do not require quantitative or qualitative differences in the RNA and protein made in cells exposed to interferon. The possible role of the ribosome in the antiviral action of interferon is also discussed.
对干扰素产生耐药性的发展取决于细胞的 RNA 合成，可能也取决于细胞的蛋白质合成。本文回顾了这些需求的证据，以及这一证据表明细胞对干扰素存在特异性反应的观点，包括诱导抗病毒蛋白的合成。尚未获得这种解释的直接证据，并且讨论了不需要干扰素暴露的细胞中 RNA 和蛋白质的数量或质量差异的替代解释。还讨论了核糖体在干扰素抗病毒作用中的可能作用。
