Institut du Radium, Département de Biologie, 91 Orsay, France.
J Gen Physiol. 1970 Jul 1;56(1):43-56. doi: 10.1085/jgp.56.1.43.
A radiobiological study of circulating interferon production in the mouse was undertaken in the hope of elucidating the site(s) of circulating interferon production. After total body X-irradiation of the animals, different radiosensitivities of circulating interferon production were observed with different viral inducers. Myxovirus-induced circulating interferon production was especially radiosensitive. Moreover, a study of interferon production in syngeneic and xenogeneic radiochimeras demonstrated that cells producing NDV (Newcastle disease virus)-induced circulating interferon were derived from hematopoietic stem cells. In addition, treatment of mice with antilymphocyte serum significantly reduced NDV- and Sendai virus-induced circulating interferon, as opposed to other inducers. Taken together, these results strongly suggest that the lymphocyte is the major source of myxovirus-induced circulating interferon. A survey of interferon production in 12 inbred mouse strains, using NDV as inducer, revealed the existence of low and high producers. A Mendelian analysis carried out with low producing Balb/c and high producing C57BL indicated that the difference between low and high interferon producers was caused by a single, autosomal, codominant factor.
进行了一项关于循环干扰素产生的小鼠放射生物学研究，希望阐明循环干扰素产生的部位。在对动物进行全身 X 射线照射后，不同的病毒诱导剂观察到不同的循环干扰素产生的辐射敏感性。粘液病毒诱导的循环干扰素产生特别敏感。此外，对同种和异种放射嵌合体中的干扰素产生的研究表明，产生 NDV（新城疫病毒）诱导的循环干扰素的细胞来源于造血干细胞。此外，用抗淋巴细胞血清处理小鼠可显著降低 NDV 和仙台病毒诱导的循环干扰素，而其他诱导剂则不然。总之，这些结果强烈表明淋巴细胞是粘液病毒诱导的循环干扰素的主要来源。使用 NDV 作为诱导剂，对 12 个近交系小鼠品系的干扰素产生情况进行了调查，发现存在低产生和高产生者。对低产生的 Balb/c 和高产生的 C57BL 进行的孟德尔分析表明，低和高干扰素产生者之间的差异是由一个单一的、常染色体、共显性因子引起的。
