[小叶黄杨石油醚部位化学成分的研究]
[Study on the constituents of petroleum ether fraction of Buxus microphylla].
作者信息
Dai Zhi-Kai, Liang Jun, Su Xiao-Jian, Xu Qing, Zhang Hui-Qin
机构信息
Guilin Medical College, Guilin 541004, China.
出版信息
Zhong Yao Cai. 2009 Jul;32(7):1062-4.
OBJECTIVE
To study the chemical constituents from the petroleum ether fraction of Buxus microphylla.
METHODS
The petroleum ether fraction of Buxus microphylla was isolated and identified by silica gel column chromatography. And the anticancer activity of different chemical constituents was measured by MTT reduction test.
RESULTS
Eight compounds were isolated and identified as lupeol (1), butulin (3), beta-sitosterol (4), stigmasterol (5), dibutyl phthalate (6), 3beta, 30-dihydroxy-lup-20 (29) ene (7), daucosterol (8). Compound 7 inhibited KB cells' proliferation in a dose-dependent manner.
CONCLUSION
Compounds 2 - 5, 7, 8 are isolated from this genus for the first time. Compound 7 has certainly anticancer effects.
目的
研究小叶黄杨石油醚部位的化学成分。
方法
采用硅胶柱色谱法对小叶黄杨石油醚部位进行分离鉴定，并通过MTT还原试验测定不同化学成分的抗癌活性。
结果
分离鉴定出8个化合物，分别为羽扇豆醇（1）、白桦脂醇（3）、β-谷甾醇（4）、豆甾醇（5）、邻苯二甲酸二丁酯（6）、3β,30-二羟基羽扇-20（29）烯（7）、胡萝卜苷（8）。化合物7对KB细胞增殖具有剂量依赖性抑制作用。
结论
化合物2 - 5、7、8为首次从该属植物中分离得到。化合物7具有一定的抗癌作用。
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