Dara Ravi Chandrabhan, Marwaha Neelam, Khetan Dheeraj, Patidar Gopal Kumar
Department of Transfusion Medicine, PGIMER, Chandigarh, India.
Indian J Hematol Blood Transfus. 2016 Sep;32(3):299-306. doi: 10.1007/s12288-015-0561-y. Epub 2015 Jun 13.
Regular blood donation can lead to iron deficiency anaemia. Early recognition and reversal of excessive iron loss by iron supplementation may avoid symptomatic iron store depletion in blood donors. The aim of this study was to assess the efficacy of iron supplementation in maintaining the iron stores of voluntary blood donors. A total of 200 regular volunteers who donated twice in previous year were randomly divided into two groups. Iron: oral iron supplementation tablets of elemental iron as ferrous fumarate. Placebo group: glucose containing capsules, to be taken once daily for 21 days after one unit of blood donation. Their hemogram, serum ferritin, red cell indices and red cell distribution width were determined at baseline and after 1 month and at the time of next blood donation. Out of 200 volunteers enrolled 98 were assigned to iron group and rest 102 into placebo group. Total of 37 % donors dropped out, yielding a dropout rate of 35 % in iron group and 39 % in the placebo group. The haemoglobin and ferritin levels showed significant improvement in iron group compared to placebo group (p < 0.05). Three weeks of oral iron therapy (98.6 mg elemental iron/day) was able to maintain iron stores at 1 month after donation but was not sufficient to sustain the iron stores over a period of 3 months. Thus there is need to evaluate increased dosage or duration of iron supplementation in maintaining the iron stores.
定期献血会导致缺铁性贫血。通过补充铁剂早期识别并纠正铁过量流失，可避免献血者出现有症状的铁储存耗竭。本研究的目的是评估补充铁剂对维持自愿献血者铁储存的疗效。共有200名在前一年献血两次的定期志愿者被随机分为两组。铁剂组：口服以富马酸亚铁形式存在的元素铁补充片。安慰剂组：含葡萄糖的胶囊，在捐献一个单位血液后每天服用一次，共服用21天。在基线、1个月后以及下次献血时测定他们的血常规、血清铁蛋白、红细胞指数和红细胞分布宽度。在纳入的200名志愿者中，98名被分配到铁剂组，其余102名被分配到安慰剂组。总共有37%的献血者退出，铁剂组的退出率为35%，安慰剂组为39%。与安慰剂组相比，铁剂组的血红蛋白和铁蛋白水平有显著改善（p<0.05）。三周的口服铁剂治疗（98.6毫克元素铁/天）能够在献血后1个月维持铁储存，但不足以在3个月的时间内维持铁储存。因此，有必要评估增加铁剂补充剂量或持续时间对维持铁储存的作用。
