Pitt J
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York.
Pediatr Clin North Am. 1991 Feb;38(1):89-95. doi: 10.1016/s0031-3955(16)38044-0.
Lymphocytic interstitial pneumonia is at present a pathologic diagnosis. In the setting of a chronic interstitial pneumonia in a child with lymphocytosis, hyperglobulinemia, and lymphadenopathy or parotid enlargement, the diagnosis is often clinically presumed. At present the diagnosis can be established firmly only by lung biopsy. Models of pathogenesis include nonspecific stimulation of the immune system, HIV-specific stimulation, or synergy between EBV and HIV. Treatment includes oxygen and bronchodilators as needed. The role of zidovudine and of steroids in the management of LIP remains to be determined.
淋巴细胞性间质性肺炎目前是一种病理学诊断。对于患有淋巴细胞增多、高球蛋白血症以及淋巴结病或腮腺肿大的儿童出现慢性间质性肺炎的情况，临床上常常会做出这种诊断。目前，只有通过肺活检才能明确诊断。发病机制模型包括免疫系统的非特异性刺激、HIV特异性刺激，或EBV与HIV之间的协同作用。治疗包括根据需要给予氧气和支气管扩张剂。齐多夫定和类固醇在淋巴细胞性间质性肺炎治疗中的作用仍有待确定。
