Yetkin F Z, Haughton V M, Papke R A, Fischer M E, Rao S M
Department of Radiology, Medical College of Wisconsin, Froedtert Memorial Lutheran Hospital, Milwaukee, WI 53226.
Radiology. 1991 Feb;178(2):447-51. doi: 10.1148/radiology.178.2.1987607.
The specificity of magnetic resonance (MR) imaging in the diagnosis of multiple sclerosis (MS) has not been measured systematically. Conventional MR head images with sagittal localizer and axial multiple-echo sequences with long repetition times were obtained in 92 patients with clinically verified MS (Schumacher criteria), 100 healthy volunteers, 60 subjects with hypertension, and eight patients with dementia. Two readers, without the aid of any clinical or demographic information, classified each of the 260 studies as MS or not MS. The readers classified the studies again after being supplied with the subjects' ages and sex. True-negative and true-positive diagnoses of MS were tabulated. The specificity of the MR diagnosis of MS (true-negative results in proportion to all non-MS studies) was 95%-99% with all the control groups included. There is a small risk of misinterpreting incidental periventricular white matter foci as plaques of MS in MR studies.
磁共振成像（MR）在多发性硬化症（MS）诊断中的特异性尚未得到系统测量。对92例临床确诊为MS（舒马赫标准）的患者、100名健康志愿者、60名高血压患者和8例痴呆患者，获取了带有矢状定位器的传统MR头部图像以及具有长重复时间的轴向多回波序列图像。两名阅片者在不借助任何临床或人口统计学信息的情况下，将这260份研究中的每一份分类为MS或非MS。在阅片者得知受试者的年龄和性别后，再次对这些研究进行分类。列出了MS的真阴性和真阳性诊断结果。纳入所有对照组后，MR诊断MS的特异性（真阴性结果占所有非MS研究的比例）为95%-99%。在MR研究中，将偶然出现的脑室周围白质病灶误判为MS斑块的风险较小。
