Loevner L A, Grossman R I, Cohen J A, Lexa F J, Kessler D, Kolson D L
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104-4283, USA.
Radiology. 1995 Aug;196(2):511-5. doi: 10.1148/radiology.196.2.7617869.
To assess for the presence of microscopic abnormalities in otherwise normal-appearing white matter on T2-weighted images in patients with multiple sclerosis (MS) by using magnetization-transfer (MT) measurements.
Twenty-three patients with MS and nine healthy control subjects underwent magnetic resonance (MR) imaging with a 1.5-T system. MT ratios (MTRs) were measured in 16 areas of normal-appearing white matter identified on conventional T2-weighted images in patients with MS. MTRs in the same white-matter locations in control subjects were determined. The two groups were compared.
The mean whole-brain MTR of normal-appearing white matter in patients was 40.13% +/- 1.37 (standard deviation; range, 36.31%-42.09%); in control subjects, 42.93% +/- 0.95 (range, 41.62%-44.50%). The difference was statistically significant (P < or = .001). Except for the internal capsules, the difference in mean MTRs in each sublocation of the brain between patients and control subjects was statistically significant (P < or = .05).
MT measurements are more sensitive than conventional MR imaging in the detection of abnormalities beyond the resolution of T2-weighted imaging.
通过使用磁化传递（MT）测量，评估多发性硬化症（MS）患者T2加权图像上外观正常的白质中微观异常的存在情况。
23例MS患者和9名健康对照者接受了1.5-T系统的磁共振（MR）成像。在MS患者常规T2加权图像上识别出的16个外观正常的白质区域测量MT比率（MTR）。确定对照者相同白质位置的MTR。比较两组。
患者外观正常白质的全脑平均MTR为40.13%±1.37（标准差；范围，36.31%-42.09%）；对照者为42.93%±0.95（范围，41.62%-44.50%）。差异具有统计学意义（P≤0.001）。除内囊外，患者与对照者大脑各亚部位的平均MTR差异具有统计学意义（P≤0.05）。
在检测超出T2加权成像分辨率的异常方面，MT测量比传统MR成像更敏感。
