消除后地区麻风病患者家庭接触者的临床、细菌学和免疫学随访 - 哥伦比亚安蒂奥基亚省。
Clinical, bacteriological and immunological follow-up of household contacts of leprosy patients from a post-elimination area - Antioquia, Colombia.
机构信息
Instituto Colombiano de Medicina Tropical, Universidad CES, Antioquia, Colombia.
出版信息
Mem Inst Oswaldo Cruz. 2009 Sep;104(6):935-6. doi: 10.1590/s0074-02762009000600021.
Follow-up of the household contacts (HHC) of leprosy patients is still the best strategy for early detection of leprosy. HHC from a post-elimination region of Colombia studied in 2001-2002 were re-contacted in 2007. They were tested at both times by clinical examination, bacillary index (BI), PCR from a slit skin smear (SSS) and anti PGL-1 IgM titres. Thirty-two of 61 HHC (52%) were re-contacted. Nine HHC (28%) showed sero-conversion and one had a skin lesion (BI negative, nested PCR positive). Periodic evaluation of HHC can contribute to the detection of infected HHC as well as new and early leprosy cases.
对麻风病患者的家庭接触者（HHC）进行随访仍然是早期发现麻风病的最佳策略。2007 年重新联系了 2001-2002 年在哥伦比亚消除地区的家庭接触者。两次均通过临床检查、细菌指数（BI）、从皮肤划痕液（SSS）进行的 PCR 以及抗 PGL-1 IgM 滴度进行检测。在 61 名家庭接触者中，有 32 名（52%）重新联系。9 名家庭接触者（28%）出现血清转换，1 名出现皮肤病变（BI 阴性，巢式 PCR 阳性）。定期评估家庭接触者有助于发现感染的家庭接触者以及新的和早期的麻风病病例。
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