Sharkevich I N
Probl Endokrinol (Mosk). 1977 Jul-Aug;23(4):99-104.
The author studied the influence of testosterone metabolite--5alpha-androstan-3beta,17beta-diol--on the development of hyperlipidemia and atherosclerosis in chinchilla rabbits given cholesterol-free semisynthetic atherogenic diet. The metabolite under study inhibited the development of hypercholesterolemia and hyperbetalipoproteinemia and decreased blood phospholipid content in the blood serum of experimental animals below the initial level. Lipid content in the sum total fraction of pre-beta and beta-lipoproteins decreased under the effect of the mentioned metabolite; there was also a fall in the amount of lipoproteins of low density and their greater saturation with cholesterol. Development of experimental atherosclerosis was intensified.
作者研究了睾酮代谢产物——5α-雄甾烷-3β,17β-二醇——对给予无胆固醇半合成致动脉粥样化饮食的毛丝鼠兔高脂血症和动脉粥样硬化发展的影响。所研究的代谢产物抑制了高胆固醇血症和高β脂蛋白血症的发展，并使实验动物血清中的血磷脂含量降至初始水平以下。在上述代谢产物的作用下，前β和β脂蛋白总组分中的脂质含量降低；低密度脂蛋白的量也减少，其胆固醇饱和度更高。实验性动脉粥样硬化的发展加剧。
