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[胸腺素对实验性高脂血症和动脉粥样硬化发展的影响]

[Effect of thymalin on the development of experimental hyperlipidemia and atherosclerosis].

作者信息

Ryzhenkov V E, Ogurtsov R P, Trubacheva V V, Popov V G, Puzyreva V P

出版信息

Vopr Med Khim. 1988 Jan-Feb;34(1):51-6.

PMID:2967015
Abstract

Thymalin, which is a polypeptide preparation from thymus, exhibited hypolipidemic and antiatherosclerotic actions in rabbits maintained on a cholesterol-containing diet during three months. At the same time, thymalin caused favourable effect on the functional activity of lymphocytes impaired in hyperlipidemic animals, i.e. it normalized the T-suppressor activity and sensitivity to atherogenic lipoproteins.

摘要

胸腺素是一种从胸腺提取的多肽制剂,在给喂食含胆固醇饲料的兔子连续喂食三个月的实验中,它展现出了降血脂和抗动脉粥样硬化的作用。与此同时,胸腺素对高脂血症动物体内受损的淋巴细胞功能活性产生了有益影响,也就是说,它使T抑制细胞活性以及对致动脉粥样硬化脂蛋白的敏感性恢复正常。

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