Department of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, #100 Tzyou 1st Road, Kaohsiung, Taiwan, ROC.
Biol Psychol. 2010 Jan;83(1):56-61. doi: 10.1016/j.biopsycho.2009.10.004. Epub 2009 Oct 29.
To reduce the care burden of dementia, identifying whether the combined effect of metabolic syndrome and epsilon4 increases the risk of cognitive decline needs to be determined. Using the Cognitive Abilities Screening Instrument (CASI), 145 mentally healthy middle-aged and older adults were recruited to investigate the influence of metabolic syndrome and epsilon4 on cognitive event-related potentials (ERPs). The results showed no difference in CASI scores, N100 and P300 measurements and epsilon4 carrier percentage between participants with and without metabolic syndrome. The epsilon4 carriers displayed a significant decrease in P300 amplitude, although the CASI scores and N100 component showed no difference. We conclude that metabolic syndrome exerts little effect on N100 and P300 measurements, and that epsilon4 carrier is an independent predictor of low P300 amplitude.
为了减轻痴呆症的护理负担，需要确定代谢综合征和 epsilon4 的联合作用是否会增加认知能力下降的风险。本研究使用认知能力筛查工具（CASI），招募了 145 名心理健康的中老年成年人，以调查代谢综合征和 epsilon4 对认知事件相关电位（ERPs）的影响。结果显示，代谢综合征患者与无代谢综合征患者的 CASI 评分、N100 和 P300 测量值以及 epsilon4 携带者百分比无差异。虽然 CASI 评分和 N100 成分没有差异，但 epsilon4 携带者的 P300 振幅显著降低。我们得出结论，代谢综合征对 N100 和 P300 测量值影响较小，而 epsilon4 携带者是 P300 振幅降低的独立预测因子。
