Espeseth Thomas, Rootwelt Helge, Reinvang Ivar
Center for the study of human cognition, Department of Psychology, University of Oslo, Box 1094, Blindern, N-0317 Oslo, Norway.
Neurosci Lett. 2009 Aug 7;459(2):91-5. doi: 10.1016/j.neulet.2009.04.053. Epub 2009 May 4.
42 individuals ranging from 47 to 73 years of age underwent an auditory three-stimulus oddball task while their event-related potentials (ERPs) were recorded. Half were APOE epsilon3 homozygotes and the remaining participants were either epsilon3/epsilon4 heterozygotes (n=13), or epsilon4 homozygotes (n=8). Analyses of variance showed that the heterozygotes had lower N1 amplitudes than the epsilon3 homozygotes, consistent with a previous study of participants with mild cognitive impairment (MCI) [I. Reinvang, T. Espeseth, L. Gjerstad, Cognitive ERPs are related to ApoE allelic variation in mildly cognitively impaired patients, Neuroscience Letters 382 (3) (2005) 346-351]. APOE genotype also significantly modulated N2 latency. epsilon4 homozygotes had longer N2 latencies, and importantly, longer N2 latencies predicted decline in verbal learning after 3.5 years follow up. These findings indicate a potential clinical significance of individual differences in ERP components N1 and N2.
42名年龄在47岁至73岁之间的个体在进行听觉三刺激Oddball任务的同时记录了他们的事件相关电位（ERP）。其中一半是APOE ε3纯合子，其余参与者要么是ε3/ε4杂合子（n = 13），要么是ε4纯合子（n = 8）。方差分析表明，杂合子的N1波幅低于ε3纯合子，这与之前一项针对轻度认知障碍（MCI）参与者的研究结果一致[I. Reinvang, T. Espeseth, L. Gjerstad，认知ERP与轻度认知障碍患者的ApoE等位基因变异有关，《神经科学快报》382 (3) (2005) 346 - 351]。APOE基因型也显著调节N2潜伏期。ε4纯合子的N2潜伏期更长，重要的是，更长的N2潜伏期预示着在3.5年的随访后言语学习能力下降。这些发现表明ERP成分N1和N2的个体差异具有潜在的临床意义。
