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APOE ε4 increases the risk of progression from amnestic mild cognitive impairment to Alzheimer's disease among ethnic Chinese in Taiwan.载脂蛋白 E ε4 增加了台湾华裔人群从遗忘型轻度认知障碍进展为阿尔茨海默病的风险。
J Neurol Neurosurg Psychiatry. 2011 Feb;82(2):165-9. doi: 10.1136/jnnp.2010.209122. Epub 2010 Jul 26.
2
Interactive effects of apolipoprotein E type 4 genotype and cerebrovascular risk on neuropsychological performance and structural brain changes.载脂蛋白 E 型 4 基因型与脑血管风险对神经心理学表现和结构脑变化的交互作用。
J Stroke Cerebrovasc Dis. 2010 Jul-Aug;19(4):261-8. doi: 10.1016/j.jstrokecerebrovasdis.2009.05.001. Epub 2010 May 14.
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The effects of metabolic syndrome and apolipoprotein E4 on cognitive event-related potentials.代谢综合征和载脂蛋白 E4 对认知事件相关电位的影响。
Biol Psychol. 2010 Jan;83(1):56-61. doi: 10.1016/j.biopsycho.2009.10.004. Epub 2009 Oct 29.
4
Cyp46 polymorphisms in Alzheimer's disease: a review.阿尔茨海默病中 Cyp46 多态性：综述。
J Mol Neurosci. 2009 Nov;39(3):342-5. doi: 10.1007/s12031-009-9227-2. Epub 2009 Aug 25.
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Cardiovascular risk factors and cognitive function.心血管危险因素与认知功能。
Alzheimers Dement. 2007 Apr;3(2 Suppl):S16-22. doi: 10.1016/j.jalz.2007.01.001.
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Fourteen-year longitudinal study of vascular risk factors, APOE genotype, and cognition: the ARIC MRI Study.血管危险因素、APOE基因分型与认知的14年纵向研究：动脉粥样硬化风险社区（ARIC）磁共振成像（MRI）研究
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7
The effects of apolipoprotein E on non-impaired cognitive functioning: a meta-analysis.载脂蛋白 E 对非受损认知功能的影响：一项荟萃分析。
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Contribution of vascular risk factors to the progression in Alzheimer disease.血管危险因素在阿尔茨海默病进展中的作用。
Arch Neurol. 2009 Mar;66(3):343-8. doi: 10.1001/archneur.66.3.343.
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Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study.胆固醇 24-羟化酶（CYP46A1）多态性与中国老年人认知功能恶化加快有关：一项为期两年的随访研究。
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代谢综合征、载脂蛋白E和CYP46对台湾华裔认知功能的影响。

Effects of metabolic syndrome, apolipoprotein E, and CYP46 on cognition among Taiwanese Chinese.

作者信息

Lai Chiou-Lian, Liou Li-Min, Liu Ching-Kuan, Yang Yuan-Han, Lin Ruey-Tay

机构信息

Department of Master's Program in Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Neurology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Department of Master's Program in Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

出版信息

Kaohsiung J Med Sci. 2014 Jul;30(7):343-9. doi: 10.1016/j.kjms.2014.03.005. Epub 2014 Apr 18.

DOI:10.1016/j.kjms.2014.03.005
PMID:24924840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11916575/
Abstract

The combined effects of metabolic syndrome and the apolipoprotein E and CYP46 genotypes on the risk of cognitive decline has yet to be determined among Taiwanese Chinese. Two hundred and nine mentally healthy middle-aged and older adults were assessed for metabolic syndrome, cognitive function using the Cognitive Abilities Screening Instrument, Mini-Mental State Examination, ApoE, and CYP46 polymorphisms. There were no differences in cognitive performance, ApoE epsilon4 (ε4) carrier status, or CYP46 genotypes between participants with and those without metabolic syndrome. The ε4 carriers and participants with the AA allele of CYP46 had significantly lower mental manipulation score. Metabolic syndrome and ε4 had synergistic effects on cognitive decline. Therefore, the ε4 carriers and participants with the AA allele of CYP46 have decreased mental manipulation ability. The metabolic syndrome may play a role in subtle cognitive dysfunction in ε4 carriers among Taiwanese Chinese.

摘要

在台湾华人中，代谢综合征与载脂蛋白E及CYP46基因多态性对认知功能衰退风险的综合影响尚未明确。对209名心理健康的中老年人进行了代谢综合征评估，使用认知能力筛查工具、简易精神状态检查表评估认知功能，并检测了载脂蛋白E（ApoE）和CYP46基因多态性。患有代谢综合征和未患代谢综合征的参与者在认知表现、ApoE ε4携带者状态或CYP46基因多态性方面并无差异。携带ε4等位基因者和具有CYP46基因AA等位基因的参与者的心理操作得分显著较低。代谢综合征和ε4等位基因对认知衰退具有协同作用。因此，携带ε4等位基因者和具有CYP46基因AA等位基因的参与者心理操作能力下降。代谢综合征可能在台湾华人携带ε4等位基因者的轻微认知功能障碍中起作用。